Results 101 to 110 of about 165,261 (263)

A cooperative release of mitochondrial DNA from platelets and neutrophils drives an interferon signature in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders

Mediators of Inflammation, 2013
Treatment of monogenic autoinflammatory disorders, an expanding group of hereditary diseases characterized by apparently unprovoked recurrent episodes of inflammation, without high-titre autoantibodies or antigen-specific T cells, has been revolutionized
Antonio Vitale, Donato Rigante, Orso Maria Lucherini, Francesco Caso, Isabella Muscari, Flora Magnotti, Maria Giuseppina Brizi, Susanna Guerrini, Maria Patti, Leonardo Punzi, Mauro Galeazzi, Luca Cantarini   +11 more
doaj   +1 more source

A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing [PDF]

, 2017
TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the ...
Agmon-Levin, Agyemang, Bain, Beachy, Beisswenger, Blau, Bulua, Cerezo, Cha, Challa, Cho, Choi, de Jesus, Dickie, Douros, Drewe, Elizabeth Drewe, Elizabeth M. McDermott, Fairclough, Federici, Fukumoto, Gomez-Hurtado, Grazziela Figueredo, Greco, Hara, Harrison, Homan, Huggins, Ian Todd, Jenna Reps, Jon Garibaldi, Kan, Lachmann, Lipinski, Lobito, Lucy C. Fairclough, Mannsperger, Marcuzzi, Martineau, McDermott, Miotto, Mohamed Hamed, Mowers, Negm, Norman, Ogino, Ola H. Negm, Park, Pathak, Patrick J. Tighe, Paul Radford, Peckham, Piram, Quintans, Rani, Rebelo, Rebelo, Reilly, Richard J. Powell, Sachse, Sardana, Sevecka, Sevecka, Sha, Shalit, Shameer, Sharon Crouch, Simon, Stahlmann, Steve St-Gallay, Susan Bainbridge, Tauber, ter Haar, Tian, Todd, Todd, Tsivkovskii, Vaitla, Voskuhl, Werber, Yoneshima, Yousaf, Zapater, Zhang, Zhang, Zhang   +85 more
core   +2 more sources

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

Arthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

Translational Psychiatry
Extant phenotypic and genetic literature has established consistent relationships between autoimmune, autoinflammatory, and psychiatric disorders. However, a comprehensive model investigating the association between a broad range of psychiatric disorders
Sophie Breunig, Younga Heather Lee, Elizabeth W. Karlson, Arjun Krishnan, Jeremy M. Lawrence, Lukas S. Schaffer, Andrew D. Grotzinger   +6 more
doaj   +1 more source

Could pentraxin-3 be a new marker for subclinical inflammation in familial Mediterranean fever? [PDF]

, 2015
Not ...
Evrengül, Harun, Karadağlı, Eda, Yüksel, Selçuk, Şenol, H.   +3 more
core   +1 more source

Mydriasis as a Secondary Effect in Patients With HLA‐B27–Associated Uveitis

Medicine Advances, EarlyView.
HLA‐B27‐associated acute anterior uveitis causes significant inflammation of the iris and anterior chamber, which disrupts normal parasympathetic control and results in increased sympathetic tone leading to pupil dilation (mydriasis). This finding can sometimes resemble herpetic uveitis, making a clinical context and careful evaluation crucial for ...
Saim Mahmood Khan, Menahil Faheem Siddiqui, Syeda Areesha Shoaib, Surraiya Riaz Mahmood Khan, Jawairya Muhammad Hussain, Syeda Faiqa Batool, Hudda Amjad   +6 more
wiley   +1 more source

Dry eye disease and spondyloarthritis: expanding the spectrum of systemic inflammatory disorders associated with ocular surface disease. Data from the international AIDA Network Spondyloarthritis Registry

Frontiers in Medicine
ObjectiveDry eye disease (DED) is a condition associated with a myriad of systemic disorders. According to recent preliminary data, axial spondylarthritis (axial-SpA) could represent a new entity associated with DED. Therefore, this study aimed to assess
Antonio Vitale, Antonio Vitale, Valeria Caggiano, Valeria Caggiano, Eduardo Martín-Nares, Nunzia Di Meglio, Nunzia Di Meglio, Cristian Sica, Cristian Sica, Andrea Hinojosa-Azaola, Maria Orsetta Perfetti, Maria Orsetta Perfetti, Alessandra Pagliara, Alessandra Pagliara, Giorgia Guidetti, Giorgia Guidetti, Alex Fonollosa, Roberta Lopez, Roberta Lopez, Jessica Sbalchiero, Jessica Sbalchiero, Jurgen Sota, Jurgen Sota, Ester Carreño, Ester Carreño, Perla Ayumi Kawakami-Campos, Stefano Gentileschi, Stefano Gentileschi, Alejandra de-la-Torre, Gian Marco Tosi, Gian Marco Tosi, Maria Antonietta Mazzei, Maria Antonietta Mazzei, Alberto Balistreri, Alberto Balistreri, Bruno Frediani, Bruno Frediani, Luca Cantarini, Luca Cantarini, Claudia Fabiani, Claudia Fabiani   +40 more
doaj   +1 more source

Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study [PDF]

, 2014
Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established.
Lo, Mindy S, Son, Mary Beth F, Sundel, Robert P, Zurakowski, David   +3 more
core   +1 more source