Results 81 to 90 of about 161,044 (231)
Predictive factors for therapeutic response and cluster analysis in syndrome of undifferentiated recurrent fever (SURF)
RMD OpenIntroduction: Syndrome of undifferentiated recurrent fever (SURF) refers to a group of recurrent fevers without a clear monogenic cause. Clinical spectrum, treatment response predictors and management strategies remain unclear. Objective: This study aims Marco Gattorno, Isabella Ceccherini, Riccardo Papa, Roberta Caorsi, Federica Penco, Stefano Volpi, Marta Ponzano, Marta Bustaffa, Ignazia Prigione, Saverio La Bella, Caterina Matucci-Cerinic, Serena Palmeri, Giada Recchi, Chiara Conti, Diana Sutera, Roberta Bertelli +15 moredoaj +1 more sourceJuvenile Gangrenous Vasculitis of the Scrotum or Scrotum Lipschütz Ulcers
JEADV Clinical Practice, EarlyView.ABSTRACT
Lipschütz genital ulcers are traditionally described in adolescent females and often linked to acute viral infections. Their male counterpart remains poorly characterised. We report a 59‐year‐old man with sudden onset of unilateral necrotic ulcers on the scrotum and inguinal region following a brief febrile episode and mild pharyngitis ...Francesco Bellinato, Paolo Gisondi, Giampiero Girolomoni +2 morewiley +1 more sourceThe International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
Allergy, EarlyView.ABSTRACT
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...T. Zuberbier, Z. Abdul Hameed Ansari, A. H. Abdul Latiff, M. M. Abuzakouk, M. S. Agcaoili‐De Jesus, R. C. Agondi, M. Al‐Ahmad, A. A. Alangari, H. Alhameli, C. D. Alonso Bello, S. Alshareef, S. Al‐Tamemi, S. Altrichter, H. Al Wahshi, S. Aquilina, M. Araújo, R. Arnaout, R. Asero, B. Ballmer‐Weber, C. Bangert, A. Bauer, M. Ben‐Shoshan, J. A. Bernstein, C. Bindslev‐Jensen, M. Bizjak, I. Boccon‐Gibod, H. Bonnekoh, L. Bouillet, K. Brockow, Z. Brzoza, M. Bulatović Ćalasan, A. Bulkhi, T. Buttgereit, A. Bygum, T. Caballero, O. Calderon, R. Campos, M. Cancian, E. Carne, M. A. Castor, I. Cerecedo, T. Çetinarslan, I. Cherrez‐Ojeda, N. Chkhikvadze, H. J. Chong‐Neto, K. Choo, G. Christoff, C.‐Y. Chu, K. Ciupka, N. Conlon, C. Costa, T. Craig, P. Criado, I. Danilycheva, R. Darlenski, E. De Arruda Chaves, L. de Montjoye, M. S. Doutre, A. Du‐Thanh, D. Ebo, S. Elkhalifa, S. Elmariah, T. El‐Shanawany, L. F. Ensina, R. Ertaş, R. Fachini Jardim Criado, M. Ferrer, S. Ferrucci, J. S. Fok, D. Fomina, L. Fonacier, G. Fouda, I. Francescantonio, A. Fukunaga, C. A. Galvan Calle, E. Garcia, K. Gáspár, A. Gelincik, S. Geng, K. Godse, M. Gonçalo, M. Gotua, C. Grattan, M. Grosber, G. Guidos Fogelbach, M. Guilarte, R. Guillod, E. Hamelmann, J. Hawkes, K. Hayama, R. Heuer, M. Hide, W. Hoetzenecker, N. Inomata, H.‐R. Kang, A. Kaplan, A. Kapp, M. Karam, A. Kasperska‐Zajac, C. H. Katelaris, A. Kessel, M. Khoshkhui, B. Kim, T. Kinaciyan, E. Kocatürk, M. Kolacinska‐Flont, P. Kolkhir, G. N. Konstantinou, M. Kosnik, D. Krasowska, K. Kulthanan, M. S. Kumaran, I. Kuprys‐Lipinska, M. Labrador, J. I. Larco, D. Larenas‐Linnemann, E. Latysheva, E. Lazaridou, P. H. Li, H. Lima, U. Lippert, M. Magerl, M. Makris, J. Alves Marcelino, A. V. Marzano, I. Medina, R. Meshkova, D. Micallef, R. Mohammed Ali, C. G. Mortz, M. Munoz, H. N. G. Oude Elberink, A. Nakonechna, I. Nasr, A. Nast, E. Netchiporouk, E. Nettis, S. Nieto, I. Ogueta Canales, T.‐L. Okas, R. L. Orfali, E. Özkaya, C. Parisi, A. Pennitz, R. Pawankar, M. P. Pereira, J. Peter, E. Petkova, P. D. Pigatto, I. Podder, T. Popov, G. Porebski, P. Pyatilova, G. D. Ramon, H. A. Ratti Sisa, M. Recto, K. Ress, K. Ridge, M. Riedl, C. Ritchie, N. Rosario Filho, I. Rosmaninho, M. Rudenko, M. Rukhadze, K. Rutkowski, V. Sabato, U. M. Sahiner, S. Saini, F. Saleh Al Sabbagh, A. Salman, F. Salvo, J. Sanchez, A. Santucci, S. Schliemann, P. Schmid‐Grendelmeier, B. E. Sekerel, F. Serpa, F. Sheikh, J. Sheikh, H. Shendi, F. Siebenhaar, M. Sonomjamts, A. Soria, B. Sousa Pinto, M. Staevska, P. Staubach, M. Stephan, K. Stevanovic, L. Stingeni, M. Stobiecki, Ö. Su Küçük, G. Sussman, A. Szegedi, S. Takahagi, A. Tanaka, N. Teovska Mitrevska, S. F. Thomsen, E. Toubi, F. Tsatsou, M. Turk, Z. Vadasz, A. Valerieva, S. Valle, M. v. Doorn, B. Veleiro Perez, C. E. Vera Ayala, C. Vestergaard, R. J. Vieira, C. W. Maruta, B. Wedi, R. N. Werner, E. W. Y. Yap, P. Xepapadaki, Y. Xiang, Y.‐M. Ye, P. Yong, G. Yosipovitch, A. Z. J. Zalewska‐Janowska, C. Zeyen, Z. Zhao, M. Metz, A. M. Giménez‐Arnau +221 morewiley +1 more sourceAutosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production
Allergy, EarlyView.IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia A. Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Jens Geginat +18 morewiley +1 more sourceDevelopment of the autoinflammatory diseases damage index (ADDI) [PDF]
, 2016 OBJECTIVES:
Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential to quantify damage in individual patients and to compare disease outcomes in clinical studies. Currently, Ravelli, A, Uziel, Y., Lachmann, HJ, Simon, A, Ombrello, A.K., Ter Haar, N.M., De Jesus, A.A., De Benedetti, F, Russo, R, Annink, KV, Brogan, PA, Ozen, S., Cattalini, M, Durrant, KL, Hachulla, E., Herlin, T., Ozen, S, Koné-Paut, I, Hoffman, HM, Della Casa Alberighi, O, Dedeoglu, F, Al-Mayouf, S.M., Dolezalova, P., Trachana, M, Papadopoulou-Alataki, E, Dolezalova, P, Frenkel, J., Haar, N.M.R. van der, Frenkel, J, Benseler, SM, Hentgen, V, Hofer, M, Jansson, AF, Benedetti, F. De, Hachulla, E, Quartier, P, Nikishina, I., Ter Haar, NM, Kuemmerle-Deschner, J.B., Cochino, A.V., Simon, A., Benseler, S.M., Kallinich, T, Gallizzi, R., Amaryan, G, Hofer, M., Gattorno, M, Kone-Paut, I., Ravelli, A., De Benedetti, F., Martini, A, Kuemmerle-Deschner, JB, Laxer, RM, De Jesus, AA, Kozlova, A, Demirkaya, E, Della Casa Alberighi, O., Kozlova, A., Hoffman, H.M., Lachmann, H.J., Cochino, AV, Insalaco, A, Anton, J., Cantarini, L., Goldbach-Mansky, R., Papadopoulou-Alataki, E., Fabio, G., Hentgen, V., Amaryan, G., Herlin, T, Rigante, D., Gattorno, M., Quartier, P., Barron, K.S., Gallizzi, R, Annink, K.V., Jansson, A.F., Laxer, R.M., Nielsen, S, Martini, A., Goldbach-Mansky, R, Alberighi, O. Della Casa, Nielsen, S., Insalaco, A., Kallinich, T., Nikishina, I, Cantarini, L, Brogan, P.A., Al-Mayouf, SM, Fabio, G, Trachana, M., Durrant, K.L., Anton, J, Ombrello, AK, Barron, KS, Demirkaya, E., Uziel, Y, Dedeoglu, F., Rigante, D, Russo, R., Jesus, A.A. De, Rigante, Donato, Cattalini, M. +102 morecore +1 more sourceHaemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases
British Journal of Pharmacology, EarlyView.Abstract
Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated, Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers +3 morewiley +1 more sourceDysfunctional immunoproteasomes in autoinflammatory diseases [PDF]
, 2016 Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding for immunoproteasomes.有持, 秀喜, Yasutomo, Koji, 60214/profile-ja.html, 50454757, 30333511, 60033/profile-ja.html, キタムラ, アキコ, ササキ, ユキ, Arimochi, Hideki, Sasaki, Yuki, 321, Kitamura, Akiko, 1521, 30311822, 676, 北村, 明子, 10448318, アリモチ, ヒデキ, 佐々木, 由紀, 1616, 273670/profile-ja.html, 安友, 康二, ヤストモ, コウジ +22 morecore An Atypical Skin Presentation of Adult‐Onset Still's Disease With Histological Description: A Case Report
Journal of Cutaneous Pathology, EarlyView.ABSTRACT
Adult‐onset Still's disease (AOSD) is an auto inflammatory disorder with a variable clinical presentation, and without a pathognomonic diagnostic test, characterized by high spiking fever, arthralgia/arthritis, a suggestive skin rash, elevated white blood cell count 10 G/L (> 80% neutrophils), elevated ferritin, with glycosylated ferritin < 20%M. Nordmann, T. Mazza, S. Menzinger, G. Kaya, S. Bogiatzi, S. Vandenberghe‐Dürr, M. Blanchard, J. Stirnemann +7 morewiley +1 more source
