Results 61 to 70 of about 194,426 (295)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A propos the Puppeteer – Jean Vigo and the Cinema of Automata

Mise au Point, 2018
This essay focuses on two central elements of the cinema of Jean Vigo that have received little attention to date: Vigo’s use of puppets, manikins, and automata as a central part in his mise-en-scène, and Vigo’s status as a transitional film maker ...
Michael Wutz
doaj   +1 more source

Intrinsic Simulations between Stochastic Cellular Automata [PDF]

, 2012
The paper proposes a simple formalism for dealing with deterministic, non-deterministic and stochastic cellular automata in a unifying and composable manner.
Arrighi, Arrighi, Delorme, Delorme, Enrico Formenti, Fates, Fatès, Gacs, Guillaume Theyssier, Hedlund, Kari, Kůrka, Maruoka, Nicolas Schabanel, Ollinger, Ollinger, Ollinger, Ollinger, Pablo Arrighi, Pivato, Rapaport, Regnault, Theyssier, Toom   +23 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Instrumental Jawārī

Al-'Usur al-Wusta, 2023
Female domestic slaves designated as jawārī (sing. jāriya) featured in a range of medieval Arabic sources, including treatises on the mechanical arts. They appeared, for example, as liquid-serving devices and timekeepers. Scholarship on automated jawārī,
Lamia Balafrej
doaj   +1 more source

Tree Automata and Automata on Linear Orderings [PDF]

RAIRO - Theoretical Informatics and Applications, 2009
Summary: We show that the inclusion problem is decidable for rational languages of words indexed by scattered countable linear orderings. The method leans on a reduction to the decidability of the monadic second-order theory of the infinite binary tree.
Bruyère, Véronique, Carton, Olivier, Sénizergues, Géraud   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Fungi as Turing automata with oracles

Royal Society Open Science
In the article, we aim to understand the responses of living organisms, exemplified by mycelium, to external stimuli through the lens of a Turing machine with an oracle (oTM).
Andrew Schumann, Andrew Adamatzky, Jerzy Król, Eric Goles   +3 more
doaj   +1 more source

Randomized Cellular Automata

, 2007
We define and study a few properties of a class of random automata networks. While regular finite one-dimensional cellular automata are defined on periodic lattices, these automata networks, called randomized cellular automata, are defined on random ...
Boccara N., NINO BOCCARA
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source