Results 71 to 80 of about 104,763 (297)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Automated Cow Body Condition Scoring Using Multiple 3D Cameras and Convolutional Neural Networks
Sensors, 2023 Body condition scoring is an objective scoring method used to evaluate the health of a cow by determining the amount of subcutaneous fat in a cow. Automated body condition scoring is becoming vital to large commercial dairy farms as it helps farmers ...
Gary I. Summerfield +3 more
doaj +1 more source
Comparing Automated and Manual Scoring Modalities for Core Lexicon Analysis
, 2022 Purpose: To advance the use of structured, monologic discourse analysis by demonstrating the reliability and accuracy of an automated scoring procedure for core lexicon. Method: 49 transcripts from persons with aphasia and 48 transcripts from persons not
Davida Fromm +6 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Validation of a Commercial Automated Body Condition Scoring System on a Commercial Dairy Farm
Animals, 2019 Body condition scoring (BCS) is the management practice of assessing body reserves of individual animals by visual or tactile estimation of subcutaneous fat and muscle.
Israel L. Mullins +4 more
doaj +1 more source
Automated Sleep Stage Scoring Using k-Nearest Neighbors Classifier
, 2020 kNNSS is a Matlab package for automated sleep stage scoring using the k-nearest neighbors algorithm. Compared to other automated sleep scoring packages its main advantage is simplicity and the use of physiologically relevant, human-interpretable ...
Stephen Morairty +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Language ValueThe rise of computer-based testing has transformed language assessment, with computer-based English speaking tests (CBESTs) offering scalable and efficient evaluations.
Hengzhi Ciel Hu, Harwati Hashim
doaj +1 more source