Results 51 to 60 of about 850,119 (312)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Personalised correction, feedback, and guidance in an automated tutoring system for skills training [PDF]
, 2008 In addition to knowledge, in various domains skills are equally important. Active learning and training are effective forms of education. We present an automated skills training system for a database programming environment that promotes procedural ...
Kenny, Claire, Pahl, Claus
core +1 more source
Evaluation of the firewall influence on the session initiation by the SIP multimedia protocol
Discrete and Continuous Models and Applied Computational Science, 2021 Firewalls is one of the major components to provide network security. By using firewalls, you can solve such problems as preventing unauthorized access, and deleting, modifying and/or distributing information under protection.
Anatoly Y. Botvinko +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
AUTOMATED INFORMATION SYSTEM OF CONTROL OF AVAILABILITY AND USING OF NATURAL RESOURCES
Системный анализ и прикладная информатика, 2017 The purpose of this work is to create an automated system for recording the availability and use of natural resources in the Republic of Belarus. To achieve this goal, the following main tasks were solved: to conduct an analytical review of similar ...
V. A. Rybak, A. Shokr
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Field-scale validation of an automated soil nitrate extraction and measurement system
, 2009 One of the many gaps that needs to be solved by precision agriculture technologies is the availability of an economic, automated, on-the-go mapping system that can be used to obtain intensive and accurate ‘real-time’ data on the levels of nitrate ...
Astatkie, T. +5 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Designing for automated construction
, 2000 The majority of automated construction research and development has been bottom-up, from the construction/engineering side rather than top-down from the design end.
A Scott Howe, S. Howe
core +1 more source
ON THE EFFECT OF ADAPTIVE USER INTERFACES ON RELIABILITY AND EFFICIENCY OF THE AUTOMATED SYSTEMS [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2014 In modern automated systems users often have to face the information overload problem because of ever increasing volumes of information with short time processing requirements.
Yu. O. Furtat
doaj