Results 71 to 80 of about 3,685,912 (292)

Automated detection of diabetic retinopathy lesions in ultra-widefield fundus images using an attention-augmented YOLOv8 framework

Frontiers in Cell and Developmental Biology
ObjectiveTo enhance the automatic detection precision of diabetic retinopathy (DR) lesions, this study introduces an improved YOLOv8 model specifically designed for the precise identification of DR lesions.MethodThis study integrated two attention ...
Lei-Si Hu, Jie Wang, Heng-Ming Zhang, Hai-Yu Huang   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Students' learning style detection using tree augmented naive Bayes [PDF]

Royal Society Open Science, 2018
Students are characterized according to their own distinct learning styles. Discovering students' learning style is significant in the educational system in order to provide adaptivity.
Ling Xiao Li, Siti Soraya Abdul Rahman
doaj   +1 more source

Automatic musical meter detection

2009 IEEE International Conference on Acoustics, Speech and Signal Processing, 2009
A method that automatically estimates the metrical structure of a piece of music is presented. The approach is based on the generation of a beat similarity matrix, which provides information about the similarity between any two beats of a piece of music.
openaire   +3 more sources

Incorporating General Incident Knowledge into Automatic Incident Detection: A Markov Logic Network Method [PDF]

, 2012
Automatic incident detection (AID) algorithms have been studied for more than 50 years. However, due to the development in some competing technologies such as cell phone call based detection, video detection, the importance of AID in traffic management ...
Liu, Min
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analyse de la production de voyelles anglaises par des apprenants francophones, l’acquisition du contraste /ɪ/–/iː/ à la lumière des k-NN

Anglophonia, 2019
Can methods of supervised learning help to evaluate the degree of acquisition of a contrast in a second language? This article addresses the issue of assessing the realizations of /ɪ/ and /iː/ by French learners of English in spontaneous conversations by
Adrien Méli, Nicolas Ballier
doaj   +1 more source