Results 71 to 80 of about 144,803 (288)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Semi-automatic object tracking in video sequences

Journal of Computer Science and Technology, 2005
A method is presented for semi-automatic object tracking in video sequences using multiple features and a method for probabilistic relaxation to improve the tracking results producing smooth and accurate tracked borders.
Federico Lecumberry, Álvaro Pardo
doaj  

Exponential sums with automatic sequences

, 2018
14 pagesInternational audienceWe show that automatic sequences are asymptotically orthogonal to periodic exponentials of type $e_q(f(n))$, where $f$ is a rational fraction, in the P\'olya-Vinogradov range.
Sary Drappeau, Drappeau, Sary, Müllner, Clemens, Clemens Müllner   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Automatic Annotation of Heart Rate Sequences

2023 IEEE 11th International Conference on Serious Games and Applications for Health (SeGAH), 2023
Heart Rate (HR) measurement is one of the most effective ways to determine whether a person is stressed or not. The analysis of a series of HR measurements can help determine whether the HR decreased, increased dramatically, or remained consistent during that time period.
Lopes, Júlio Castro, Vieira, João, Antunes, Alexandre Fernandes, Deusdado, Leonel, Lopes, Rui Pedro   +4 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

An Activity Rule Based Approach to Simulate ADL Sequences

IEEE Access, 2018
The concept of activities of daily living (ADL) has for many years successfully been used in a broad range of health and health care applications. Recent hardware and software developments suggest that the future use of ADL will not only benefit from the
Stein Kristiansen, Thomas P. Plagemann, Vera Goebel   +2 more
doaj   +1 more source

Ship-Collision Avoidance Decision-Making Learning of Unmanned Surface Vehicles with Automatic Identification System Data Based on Encoder—Decoder Automatic-Response Neural Networks

Journal of Marine Science and Engineering, 2020
Intelligent unmanned surface vehicle (USV) collision avoidance is a complex inference problem based on current navigation status. This requires simultaneous processing of the input sequences and generation of the response sequences.
Miao Gao, Guo-You Shi
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source