Results 41 to 50 of about 37,927 (278)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Shock Absorbers Multi-Modeling and Suspension Optimization [PDF]
Journal of Electrical and Electronics Engineering, 2013 The standard dampers used by more 90% of vehicles have damping coefficients constant along stroke, so they can’t solve simultaneous all of them, situation solving practically using a relative dampingcoefficient able to made compromise between them.
LUPU Ciprian +3 more
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
, 2011 In an extensive wood combustion source test series 2 automatically and 2 manually fired appliances, and 8 fuel types were investigated with respect to their particulate (PM10) and gaseous emissions.
Handler, Markus +19 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Lighting Control System Based on the RTP of Smart Grid in WSN
International Journal of Distributed Sensor Networks, 2015 This paper proposes a lighting control system based on RTP to save lighting energy cost by utilizing daylight while maintaining target luminance suited to the purpose.
Kyoung-Mi Im, Jae-Hyun Lim
doaj +1 more source
METHOD FOR REDUCTIVE PRUNING OF NEURAL NETWORKS AND ITS APPLICATIONS
Компютерні системи та інформаційні технології, 2022 Trained neural networks usually contain redundant neurons that do not affect or degrade the quality of target identification. The redundancy of models possesses an excessive load on computational resources, leading to high electricity consumption ...
Oleksandr Gurbych, Maksym Prymachenko
doaj +1 more source
Perceptual and Cognitive Load Interact to Control the Spatial Focus of Attention
, 2011 Caparos and Linnell (2009, 2010) used a variable-separation flanker paradigm to show that (a) when cognitive load is low, increasing perceptual load causes spatial attention to focus and (b) when perceptual load is high, decreasing cognitive load causes ...
Karina J. Linnell +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source