Results 81 to 90 of about 212,785 (269)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Particle Swarm Optimization-Enhanced Fuzzy Control for Electrical Conductivity Regulation in Integrated Water–Fertilizer Irrigation Systems

open access: yesAutomation
Traditional water–fertilizer control systems often suffer from poor precision and slow response, limiting precision agriculture development. This study developed an electrical conductivity (EC) control system for water–fertilizer integration using a ...
Jin Yang, Xue Li, Quan Zheng, Lichao Liu
doaj   +1 more source

An Automated Osmometer

open access: yesClinical Chemistry, 1968
Abstract A freezing-point apparatus, which measures osmotic pressure by determining freezing-point depression, was modified by incorporating a slowly rotating circular tray with space for 30 sample vials, and a sample pick-up device. The instrument is designed to automatically pick up a cuvet containing a 2-ml.
D T, Forman, G C, Changus
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Real-Flight-Path Tracking Control Design for Quadrotor UAVs: A Precision-Guided Approach

open access: yesAutomation
This study presents the design and implementation of a real-time flight-path tracking control system for a quadrotor unmanned aerial vehicle (UAV) capable of accurately following a mobile ground target under dynamic and uncertain environmental conditions.
Moataz Aly   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Toward Autonomous Pavement Inspection: An End-to-End Vision-Based Framework for PCI Computation and Robotic Deployment

open access: yesAutomation
Advancements in robotics and computer vision are transforming how infrastructure is monitored and maintained. This paper presents a novel, fully automated pipeline for pavement condition assessment that integrates real-time image analysis with PCI ...
Nada El Desouky   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Evaluation of Pavement Marking Damage Degree Based on Rotating Target Detection in Real Scenarios

open access: yesAutomation
Damaged road markings are widespread, and timely detection and repair of severely damaged areas is critical to the maintenance of transport infrastructure.
Zheng Wang   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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