Results 111 to 120 of about 1,631 (277)

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Range estimation of autonomous shuttles in Linköping

In this study, the range estimation for a shuttle is proposed by presenting a statistical methodology to find vehicle physical parameters and applying an estimator algorithm to the remaining energy consumption calculation for the HVAC system coefficients’
Sundström, Christofer,, Kharrazi, Sogol,, Kuvvetli, Ipek,   +2 more
core  

Mobility of the Future - Success Factors for the Integration of autonomous Shuttles into Public Transport

321337Die vorliegende Arbeit dokumentiert die Ergebnisse aus der dritten Projektphase des Reallabors AMEISE, das sich mit der Einführung und Skalierung autonomer Shuttles im ÖPNV beschäftigt.
Feldwieser, Martin, Ciziroglou, Philipp, Yapici, Cansu   +2 more
core   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Understanding the Catalytic Determinant role of Diaphorase‐Like Subunit in Formate Dehydrogenases via Redox Couples

Advanced Science, EarlyView.
A unique mechanism of catalytic bias regulated by diaphorase‐like subunit in formate dehydrogenase from Rhodobacter aestuarii is revealed. The diaphorase‐like subunit functions act as a biological “voltage rheostat” that controls the slow release of NADH to regulate redox balance, biasing the enzyme's catalytic preference toward CO2 reduction over ...
Kuncheng Zhang, Weisong Liu, Hao Su, Huijuan Cui, Yuanming Wang, Zhiguang Zhu, Chun You, Lingling Zhang   +7 more
wiley   +1 more source

Enhancing the Safety of Autonomous Vehicles: Semi-Supervised Anomaly Detection With Overhead Fisheye Perspective

IEEE Access
Autonomous vehicles (AVs) have the potential to revolutionize transportation. However, ensuring passenger safety within these vehicles in the absence of a dedicated onboard authority figure necessitates the development of intelligent, autonomous ...
Dimitris Tsiktsiris, Antonios Lalas, Minas Dasygenis, Konstantinos Votis   +3 more
doaj   +1 more source

Veterans’ Perceptions of Shared Autonomous Electric Shuttles: A Pre- and Post-Exposure Assessment

Veterans often face transportation barriers, but advances in technology enable real-world testing of shared autonomous electric vehicles as potential energy-efficient solutions.
Sherrilene Classen, Justin Mason, Isabelle Wandenkolk, Seung Woo Hwangbo   +3 more
core   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Assessing Veterans’ Lived Experiences After Exposure to an Autonomous Shuttle

Future Transportation
Transportation is often cited as a significant barrier to healthcare access by Veterans, particularly those from minority groups, who have disabilities, or live in rural areas. Autonomous shuttles (AS) offer a potential solution, yet limited research has
Isabelle Wandenkolk, Sherrilene Classen, Nichole E. Stetten, Seung Woo Hwangbo, Kelsea LeBeau   +4 more
doaj   +1 more source