Results 51 to 60 of about 346,125 (318)

Insight Under Scrutiny in the Court of Protection: A Case Law Survey

Frontiers in Psychiatry, 2020
The concept of patient insight, of a patient’s self-awareness of illness or impairment (and related issues), plays a significant role in clinical discourse and clinical practice.
Sándor Gurbai, Sándor Gurbai, Sándor Gurbai, Emily Fitton, Wayne Martin, Wayne Martin   +5 more
doaj   +1 more source

Cognition, Behavior, Sexuality, and Autonomic Responses of Women with Hypothalamic Amenorrhea [PDF]

, 2022
Carlo Pruneti, Sara Guidotti
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Temporal Graph Traversals Using Reinforcement Learning With Proximal Policy Optimization

IEEE Access, 2020
Graphs in real-world applications are dynamic both in terms of structures and inputs. Information discovery in such networks, which present dense and deeply connected patterns locally and sparsity globally can be time consuming and computationally costly.
Samuel Henrique Silva, Adel Alaeddini, Peyman Najafirad   +2 more
doaj   +1 more source

Correlations between vegetative autonomic function and specific left atrial functions in healthy adults: Insights from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study [PDF]

, 2023
Attila Nemes, Árpád Kormányos, Andrea Orosz, Nóra Ambrus, Tamás Várkonyi, Csaba Lengyel   +5 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Accumulation in nutrient acquisition strategies of arbuscular mycorrhizal fungi and plant roots in poor and heterogeneous soils of karst shrub ecosystems

BMC Plant Biology, 2022
Background Arbuscular mycorrhizal (AM) fungi and roots play important roles in plant nutrient acquisition, especially in nutrient poor and heterogeneous soils.
Yueming Liang, Fujing Pan, Zhongcheng Jiang, Qiang Li, Junbing Pu, Kunping Liu   +5 more
doaj   +1 more source

Autonomy: Simulation's Next Events [PDF]

Proceedings of 1993 Winter Simulation Conference - (WSC '93), 1993
Simulation is facing the challenge to support ever increasingly complex phenomena characterized by autonomous behavior. This paper discusses an approach with which to investigate the wider modeling and analysis issues raised by these demand.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source