Results 71 to 80 of about 1,765,605 (361)

The foundations of conscientious objection: against freedom and autonomy [PDF]

open access: yes, 2018
According to the common view, conscientious objection is grounded in autonomy or in ‘freedom of conscience’ and is tolerated out of respect for the objector's autonomy.
Danaher, John, Nehushtan, Yossi
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Validity of the Walked Distance Estimated by Wearable Devices in Stroke Individuals

open access: yesSensors, 2019
Background: Health professionals need valid devices to assess a stroke individual’s ability to walk. The aim was to evaluate the validity of the estimation of the walked distance by wearable devices and the impact of the sensor’s position in ...
Maxence Compagnat   +6 more
doaj   +1 more source

How Autonomy Can Legitimate Beneficial Coercion [PDF]

open access: yes, 2017
Respect for autonomy and beneficence are frequently regarded as the two essential principles of medical ethics, and the potential for these two principles to come into conflict is often emphasised as a fundamental problem.
White, Lucie
core  

Antecedents of burnout among elite dancers: a longitudinal test of basic needs theory [PDF]

open access: yes, 2011
Objectives: Little is known regarding the social-psychological predictors of burnout in the dance domain. Drawing from basic needs theory, a sub-theory in the self-determination theory framework (Deci & Ryan, 2000), this study examined whether changes in
Duda, Joan L, Quested, Eleanor
core   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

open access: yesFEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel   +8 more
wiley   +1 more source

Entropy as a Robustness Marker in Genetic Regulatory Networks

open access: yesEntropy, 2020
Genetic regulatory networks have evolved by complexifying their control systems with numerous effectors (inhibitors and activators). That is, for example, the case for the double inhibition by microRNAs and circular RNAs, which introduce a ubiquitous ...
Mustapha Rachdi   +3 more
doaj   +1 more source

Implementation of a patient‐reported experience measure in a Dutch disability care organization: A process evaluation of cocreated tailored strategies

open access: yesHealth Expectations, 2023
Introduction In 24/7 disability care facilities, patient‐reported experience measures (PREMs) are important to help healthcare professionals understand what matters to care users and to improve the quality of care.
Marjolein vanRooijen   +5 more
doaj   +1 more source

Informed Consent Without Autonomy [PDF]

open access: yes, 2002
This Essay explains why and how the Roman Catholic basis for informed consent is different from the secular basis. It argues that the Catholic basis, which is rooted in natural law, is the better model for society to adopt.
Sulmasy, Daniel P.
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

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