Results 171 to 180 of about 1,007,449 (349)

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition.

Clinical science, 2019
Macrophage polarization towards the M1 phenotype and its subsequent inflammatory response have been implicated in the progression of diabetic complications.
Yujia Yuan, Younan Chen, T. Peng, Lan Li, Wuzheng Zhu, Fei Liu, Shuyun Liu, Xingxing An, Ruixi Luo, Jingqiu Cheng, Jingping Liu, Yanrong Lu   +11 more
semanticscholar   +1 more source

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. [PDF]

, 2020
BackgroundThe trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases ...
Arkin, Michelle, Boxer, Adam L, Chen, Xu, Cuervo, Ana Maria, Gan, Li, Gestwicki, Jason E, Karydas, Anna, Li, Yaqiao, Miller, Bruce L, Mok, Sue-Ann, Rojas, Julio C, Tang, Yinyan, Tsai, Richard M, Wang, Chao   +13 more
core  

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Oxidative Medicine and Cellular Longevity, 2019
Oxidative stress-induced mitochondrial dysfunction and nucleus pulposus (NP) cell apoptosis play crucial roles in the development of intervertebral disc degeneration (IDD).
Liang Kang, Q. Xiang, Shengfeng Zhan, Yu Song, Kun Wang, K. Zhao, Shuai Li, Zengwu Shao, Cao Yang, Yukun Zhang   +9 more
semanticscholar   +1 more source

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3 [PDF]

, 2018
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer.
Amézaga, Núria, Aran, Gemma, Armengol, Carolina, López Codina, Daniel, Prats Soler, Clara, Sanjurjo, Lucía, Sarrias, Maria Rosa, Téllez, Érica   +7 more
core   +2 more sources

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells

Stem Cell Research & Therapy, 2019
Background Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucidation.
Zheng Li, Shuhao Liu, Tengfei Fu, Yi Peng, Jian Zhang   +4 more
doaj   +1 more source

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources