Results 261 to 270 of about 1,007,449 (349)

5'-Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation-Mediated PAK2 Upregulation to Promote Cadmium-Induced Breast Cancer Progression by Impairing Autophagic Flux. [PDF]

Adv Sci (Weinh)
Li J, Deng P, Fan T, Qu Y, Tan M, Liang Y, Gao P, Peng Y, Qin M, Jie S, Hao R, Wang L, Zhang L, Chen C, He M, Ma Q, Luo Y, Tian L, Xie J, Chen M, Tian R, Li M, Yu Z, Zhou Z, Pi H.   +24 more
europepmc   +1 more source

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology. [PDF]

Autophagy
Zhang C, Huang Z, Huang X, Ma Y, Cao Y, Zhang Z, Wang R, Ren H, Zheng L, Liu CF, Wang G.   +10 more
europepmc   +1 more source

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

Exploring Dapagliflozin's Influence on Autophagic Flux in Mania-like Behaviour: Insights from the LKB1/AMPK/LC3 Pathway in a Mouse Model. [PDF]

J Neuroimmune Pharmacol
Saleh NK, Farrag SM, El-Yamany MF, Kamel AS.   +3 more
europepmc   +1 more source

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK [PDF]

, 2017
Austin, Christopher P., Dai, Sheng, Dulcey, Andres E., Hu, Xin, Marugan, Juan, Ory, Daniel S., Porter, Forbes D., Wassif, Christopher A., Zheng, Wei   +8 more
core   +2 more sources

A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination‐Mediated Degradation That Promotes Bacterial Infection

Plant Biotechnology Journal, EarlyView.
ABSTRACT Autophagy and the ubiquitin/26S proteasome system (UPS) play critical roles in the immune defence of the host against pathogen invasion. As a countermeasure, pathogens deploy effector proteins to subvert or hijack autophagy and UPS processes.
Yaqian Shi, Fang Fang, Xuejin Cui, Hongwei Shi, Zaiyu Yang, Xueyi Li, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source

PARP inhibitors accumulate B7-H3 on fibroblasts via blocking autophagic flux to potentiate immune evasion in ovarian cancer. [PDF]

Oncoimmunology
Fang T, Xia Y, Li Y, Xu S, Li H, Wang S, Huang P, Qian Y, Jin P, Jin N, Xu C, Wang Z, Xiong X, Wang M, Zhou D, Wang Y, Li X, Xu T, Zhang Q, Liu D, Fang Y, Zhao GN, Gao Q.   +22 more
europepmc   +1 more source

A Highly Conserved SNARE‐Associated Protein Enhances Plant Immunity by Regulating Vesicle Trafficking

Plant Biotechnology Journal, EarlyView.
ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk, Peitong Li, Hafiz Muhammad Khalid Abbas, Mst Shamira Sultana, Sarbottam Piya, Nicole Coffey, Cengizhan Öztürk, Sobhan Bahrami Zadegan, Susan Thomas Laird, Mazen Alazem, Samantha P. Nuzzi, J. Hollis Rice, Chris Wyman, Tessa Burch‐Smith, Vince Pantalone, Tarek Hewezi   +15 more
wiley   +1 more source

Macrocyclic Diterpenoids from <i>Euphorbia peplus</i> Possessing Activity Towards Autophagic Flux. [PDF]

Int J Mol Sci
Chen L, Liu L, Li Y, Guan S, Fan L, Qin X, Di Y, Tang L, Luo R, Yan Y.   +9 more
europepmc   +1 more source