Results 291 to 300 of about 1,007,449 (349)

A Novel 14mer Peptide Inhibits Autophagic Flux via Selective Activation of the mTORC1 Signalling Pathway: Implications for Alzheimer's Disease. [PDF]

Int J Mol Sci
García Porta C, Mahfooz K, Komorowska J, Garcia-Rates S, Greenfield S.   +4 more
europepmc   +1 more source

ROC‐325 Attenuates Hypoxia‐Induced Pulmonary Hypertension Through Dual Inhibition of Autophagy and Hypoxia‐Inducible Factor 2α Signaling

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
In hypoxia‐induced pulmonary hypertension, endothelial HIF‐2α accumulation and autophagic activation drive vascular remodeling. We demonstrate that the novel lysosomal inhibitor ROC‐325 simultaneously attenuates this pathogenic autophagy and promotes HIF‐2α degradation.
Changlei Bao, Shuxin Liang, Dingyuan Liu, Xingting Wang, Dan Bai, Chuangjia Huang, Hanliang Sun, Zi Yang, Bitao Wu, Zixuan Chen, Jieyi Feng, Zinan Luo, Jintao Long, Jinsheng Zhu, June Bai, Li Zhang, Aiai Chu, Caojin Zhang, Haiyang Tang   +18 more
wiley   +1 more source

Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation. [PDF]

Acta Pharmacol Sin
He LN, Liu YJ, Jiang JB, Wang DY, Li YL, Zeng SJ, Guo Z, Yao PY, Lin ZC, Lv SX, Liu XY, Guo W, Liu F, Du BY, Zhao TX, Xiao JY, Shi YF, Wang K.   +17 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

ROS-DRP1-mediated excessive mitochondrial fission and autophagic flux inhibition contribute to heat stress-induced apoptosis in goat Sertoli cells. [PDF]

J Anim Sci Biotechnol
Wen F, Gao J, Zhang G, Guo S, Zhang X, Han S, Feng X, Chen X, Hu J.   +8 more
europepmc   +1 more source

Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Acta Ophthalmologica, Volume 104, Issue 2, Page 239-251, March 2026.
Abstract Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Methods Human cadaver macula samples representing dry and wet AMD, as well as age‐matched controls, were ...
Iswariyaraja Sridevi Gurubaran, Ali Koskela, Hanna Heloterä, Kai Kaarniranta   +3 more
wiley   +1 more source

Autophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis. [PDF]

Cell Death Discov
Liu X, Sun X, Mu W, Li Y, Bu W, Yang T, Zhang J, Liu R, Ren J, Zhou J, Li P, Shi Y, Shao C.   +12 more
europepmc   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux. [PDF]

Redox Biol
Wang X, Huang X, Zhang Y, Huo H, Zhou G, Shen L, Li L, He B.   +7 more
europepmc   +1 more source

Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice

Immunology, Volume 177, Issue 3, Page 481-500, March 2026.
The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han, Xi Xu, Yan Zhao, Yao Xiao, Fei Huang, Jing Zhou, Hai Huang, Guiqian Wang   +7 more
wiley   +1 more source