Results 201 to 210 of about 58,150 (299)

Oxidative Stress-Induced Age-Related Bullous Keratopathy in Corneal Endothelial Cells With Lipid Droplets and Vacuoles. [PDF]

Invest Ophthalmol Vis Sci
Onouchi H, Yamasaki H, Toda R, Taniguchi T, Suzuki T, Suzuki Y, Ishii N, Ishii T.   +7 more
europepmc   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

MYO5A-mediated stabilization promotes the acquisition of fusion competence in sealed autophagosomes. [PDF]

EMBO J
Nambiar A, Martin R, Tomar K, Knölker HJ, Koushika SP, K S, Manjithaya R.   +6 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

NIBV Induces Incomplete Autophagy via AMPK-TFEB, Causing Kidney Injury in Chicks. [PDF]

Adv Sci (Weinh)
Huang C, Zeng Y, Chen Y, Li Z, Omar SM, Zhong S, Liu P, Zheng Z, Cai G, Gao X, Guo X.   +10 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Dangerous Membranes: Viruses That Subvert Autophagosomes

EBioMedicine, 2014
William T. Jackson
doaj   +1 more source

Metformin Alleviates Cadmium-Induced Autophagic Flux Impairment-Dependent Apoptosis by Activating AMPK in Neuronal Cells. [PDF]

Cells
Wu W, Chen X, Ji T, Yu Q, Hou L, Zhou Z, Gong B, Xu M, Gao W, Huang S, Chen L.   +10 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Targeted autophagy: research progress on the regulatory potential of periodontitis prevention and treatment. [PDF]

Front Cell Dev Biol
Wang Y, Fu Z, Wu Y.
europepmc   +1 more source