Results 141 to 150 of about 286,383 (199)

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury

Advanced Science, EarlyView.
Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo, Rui Wang, Jingwen Gong, Shuting Wang, Chuan Yun, Zongcun Chen, Yanan Jiang, Xiaoquan Liu, Haofu Dai, Haochen Liu, Yunsi Zheng   +10 more
wiley   +1 more source

The role of Bcl‑2 in controlling the transition between autophagy and apoptosis (Review). [PDF]

Mol Med Rep
Palabiyik AA.
europepmc   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF. [PDF]

Sci Rep
Zhou W, Wang J, Ding L, Cai R, Cheng J, Liang P, Zhu Y, Zhang Z.   +7 more
europepmc   +1 more source

Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine

Advanced Science, EarlyView.
A novel self‐assembled nanomedicine (PMDDH) has been developed for the co‐delivery of doxorubicin and metformin, aiming to enhance the anti‐tumor efficacy of doxorubicin while alleviating its cardiotoxicity through the activation of cGAS‐STING and AMPK signaling pathways, respectively.
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen   +9 more
wiley   +1 more source

Autophagy: molecular machinery for self-eating [PDF]

, 2005
Tomohiro Yorimitsu, Daniel J. Klionsky
openalex   +1 more source

The role of autophagy in cancer: from molecular mechanism to therapeutic window. [PDF]

Front Immunol
Jalali P, Shahmoradi A, Samii A, Mazloomnejad R, Hatamnejad MR, Saeed A, Namdar A, Salehi Z.   +7 more
europepmc   +1 more source

Targeted DNA Nanomachine Enables Specific miRNA‐Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy

Advanced Science, EarlyView.
An intelligent DNA nanomachine based on DNA tetrahedron is proposed, incorporated with aptamer and specific miRNA‐responsive hairpin catalytic assembly (HCA), for precise therapy of cutaneous squamous cell carcinoma (cSCC) in mice, with barely systemic toxicity and inflammation.
Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie, Wenhu Zhou, Shuang Zhao   +9 more
wiley   +1 more source

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death [PDF]

, 2005
Geir Bjørkøy, Trond Lamark, Andreas Brech, Heidi Outzen, Maria Perander, Aud Øvervatn, Harald Stenmark, Terje Johansen   +7 more
openalex   +1 more source

Transcriptomic profiling of autophagy and apoptosis pathways in liver cancer cells treated with a new tyrosine kinase inhibitor PD161570. [PDF]

Mol Med Rep
He X, Liu J, Zhang Y, Xie B.
europepmc   +1 more source