Results 151 to 160 of about 401,976 (308)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Prognostic feature based on androgen-responsive genes in bladder cancer and screening for potential targeted drugs

BioData Mining
Objectives Bladder cancer (BLCA) is a tumor that affects men more than women. The biological function and prognostic value of androgen-responsive genes (ARGs) in BLCA are currently unknown.
Jiang Zhao, Qian Zhang, Cunle Zhu, Wu Yuqi, Guohui Zhang, Qianliang Wang, Xingyou Dong, Benyi Li, Xiangwei Wang   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Autophogy Protects Neuron from a Beta-Induced Cytotoxicity

, 2010
Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extracellular accumulation of P-amyloid peptide has been reported to be a major cause of Alzheimer disease (AD) and large numbers of ...
洪詩雅;黃偉邦;劉鴻祺;符文美, HUNG, SHIH-YA;HUANG, WEI-PANG;LIOU, HOUNG-CHI;FU, WEN-MEI   +1 more
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MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling

, 2016
MARCH2 (membrane-associated RING-CH protein 2), an E3 ubiquitin ligase, is mainly associated with the vesicle trafficking. In the present study, for the first time, we demonstrated that MARCH2 negatively regulates autophagy.
Liujing Qu (412279), Lin, Xin, Xin Lin (149944), Dan Xia (1775776), He, Qihua, Li, Ge, Yaxin Lou (686919), Dalong Ma (412281), Qu, Liujing, Yingyu Chen (161120), Xu, Chentong, Lou, Yaxin, Hongdu, Beiqi, Chentong Xu (2832008), Beiqi Hongdu (2832011), Ma, Dalong, Qihua He (644192), Xia, Dan, Chen, Yingyu, Ge Li (65539)   +19 more
core   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Exploring the Therapeutic Potential of β-Hydroxybutyrate (BHB) in Clear Cell Renal Cell Carcinoma: A Journey into Fat Browning, Autophagy, and Tumor Slimming

International Journal of Clinical Practice
This study delves into the therapeutic potential of β-hydroxybutyrate (BHB) in clear cell renal cell carcinoma (ccRCC), a cancer known for its complex pathogenesis and resistance to conventional treatments.
Roya Rezaei, Asra Abdali Larki, Rosa Hosseinzadegan, Zahra Dashti, Saba Tarkashvand, Reihaneh Akhoondi, Morvarid Siri, Mesbah Shams, Alireza Monsef, Sanaz Dastghaib   +9 more
doaj   +1 more source

Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

, 2019
We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues ...
Francisco Canet, Rafael Alós, Sara Calatayud, María D. Barrachina, Dulce C. Macias-Ceja, Laura Gisbert-Ferrándiz, Dolores Ortiz-Masiá, Jesus Cosin-Roger, Francisco Navarro, Juan V. Esplugues   +9 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

, 2013
[[sponsorship]]生物醫學科學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Drexel&SrcApp=hagerty_opac&KeyRecord=1554-8627&DestApp=JCR&RQ=IF_CAT_BOXPLOT[[note]]http://gateway.isiknowledge.com ...
Klionsky, DJ;Abdalla, FC;Abeliovich, H;Abraham, RT;Acevedo-Arozena, A;Adeli, K;Agholme, L;Agnello, M;Agostinis, P;Aguirre-Ghiso, JA;Ahn, HJ;Ait-Mohamed, O;Ait-Si-Ali, S;Akematsu, T;Akira, S;Al-Younes, HM;Al-Zeer, MA;Albert, ML;Albin, RL;Alegre-Abarrategui, J;Aleo, MF;Alirezaei, M;Almasan, A;Almonte-Becerril, M;Amano, A;Amaravadi, R;Amarnath, S;Amer, AO;Andrieu-Abadie, N;Anantharam, V;Ann, DK;Anoopkumar-Dukie, S;Aoki, H;Apostolova, N;Arancia, G;Aris, JP;Asanuma, K;Asare, NY;Ashida, H;Askanas, V;Askew, DS;Auberger, P;Baba, M;Backues, SK;Baehrecke, EH;Bahr, BA;Bai, XY;Bailly, Y;Baiocchi, R;Baldini, G;Balduini, W;Ballabio, A;Bamber, BA;Bampton, ET;Bánhegyi, G;Bartholomew, CR;Bassham, DC;Bast Jr, RC;Batoko, H;Bay, BH;Beau, I;Béchet, DM;Begley, TJ;Behl, C;Behrends, C;Bekri, S;Bellaire, B;Bendall, LJ;Benetti, L;Berliocchi, L;Bernardi, H;Bernassola, F;Besteiro, S;Bhatia-Kissova, I;Bi, X;Biard-Piechaczyk, M;Blum, JS;Boise, LH;Bonaldo, P;Boone, DL;Bornhauser, BC;Bortoluci, KR;Bossis, I;Bost, F;Bourquin, JP;Boya, P;Boye
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