Results 241 to 250 of about 449,405 (356)

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

The crosstalk of caveolin-1 and autophagy in different diseases. [PDF]

Front Immunol
Yang Y, Ma Q, Yang M, Wei R, Wang Z, Jiang C, Liu H, Han M.   +7 more
europepmc   +1 more source

Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy [PDF]

, 2004
Casper Paludan, Dorothee Schmid, Markus Landthaler, Martina Vockerodt, Dieter Kube, Thomas Tuschl, Christian Münz   +6 more
openalex   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Autophagy-Related Proteins in Triple-Negative Breast Cancer: From Molecular Insights to Therapeutic Applications. [PDF]

Int J Mol Sci
Ma MK, Li DQ.
europepmc   +1 more source

Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells [PDF]

, 2004
Hayato Takeuchi, Takao Kanzawa, Yasuko Kondo, Seiji Kondo   +3 more
openalex   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Autophagy inhibition in LGALS9-overexpressing nasopharyngeal carcinoma unleashes immune response. [PDF]

Autophagy
Pascual C, Klionsky DJ, Klionsky DJ.
europepmc   +1 more source

A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy

, 2002
Zhenyu Yue, Antony Horton, Monica Bravin, Philip L. DeJager, Fekrije Selimi, Nathaniel Heintz   +5 more
openalex   +1 more source

Ald6p Is a Preferred Target for Autophagy in Yeast, Saccharomyces cerevisiae [PDF]

, 2004
Jun Onodera, Yoshinori Ohsumi
openalex   +1 more source