Results 271 to 280 of about 449,405 (356)

Microglial Autophagy and Mitophagy in Ischemic Stroke: From Dual Roles to Therapeutic Modulation. [PDF]

Biology (Basel)
Wu J, Liu J, Li Y, Du F, Li W, Thilakavathy K, Lim JCW, Sun Z, Deng J.   +8 more
europepmc   +1 more source

Molecular definitions of autophagy and related processes

EMBO Journal, 2017
L. Galluzzi, E. Baehrecke, A. Ballabio, P. Boya, J. M. Bravo-San Pedro, F. Cecconi, A. Choi, C. Chu, P. Codogno, M. Colombo, A. Cuervo, Jayanta Debnath, V. Deretic, I. Dikič, E. Eskelinen, G. Fimia, S. Fulda, D. Gewirtz, D. Green, M. Hansen, J. Harper, M. Jäättelä, T. Johansen, G. Juhász, Alec C. Kimmelman, C. Kraft, N. Ktistakis, Sharad Kumar, B. Levine, C. López-Otín, F. Madeo, Sascha Martens, Jennifer Martinez, A. Meléndez, N. Mizushima, C. Münz, Leon O. Murphy, J. Penninger, M. Piacentini, F. Reggiori, D. Rubinsztein, K. Ryan, L. Santambrogio, L. Scorrano, A. Simon, H. Simon, A. Simonsen, Nektarios Tavernarakis, S. Tooze, T. Yoshimori, Junying Yuan, Zhenyu Yue, Q. Zhong, G. Kroemer   +53 more
semanticscholar   +1 more source

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Advanced Science, EarlyView.
ASP aggravates TEC injury and phenotypic transformation via mitochondrial dynamics disorder mediated by excessive Drp1 SUMOylation in DKD mice. However, either ASP deficiency or AASP effectively alleviates the kidney injury and mitochondrial dynamics disorder induced by STZ/HFD, highlighting that ASP could be an early diagnostic marker and potential ...
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang   +8 more
wiley   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Programmed Cell Death in Diabetic Kidney Disease: Mechanisms and Therapeutic Targeting. [PDF]

J Inflamm Res
Tang S, Sun Y, Sun W, Kang X, Zhao X, Jiang L, Gao Q, An X, Ji H, Lian F.   +9 more
europepmc   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Autophagy and porcine circovirus infection: a mini review. [PDF]

Front Cell Infect Microbiol
Chen X, Chen X, Yu Z.
europepmc   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

MicroRNA-mediated regulation of autophagy in lung cancer: role in tumourigenesis and chemotherapy resistance. [PDF]

Acad Oncol
Sheng YY, Shakerdi AL, Pidgeon GP.
europepmc   +1 more source

Targeting autophagy in cancer

Cancer, 2018
Angelique Onorati, Matheus Dyczynski, Rani Ojha, R. Amaravadi   +3 more
semanticscholar   +1 more source