Results 271 to 280 of about 687,627 (397)

Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures

, 2017
Jennifer Jung, Christian Behrends
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Piezo1-mediated autophagy promotes immune-inflammatory responses in ankylosing spondylitis. [PDF]

Cell Death Dis
Zhao H, Yu X, Jiang M, Li Z, Zhao Y, Ren Y, Fang L, Wang M, Lu X, Ma Y, Wang G, Zhou Q, Zou Y, Cai G, Pan F.   +14 more
europepmc   +1 more source

The role of autophagy and the lysosomal pathway in the clearance of Tau aggregates

, 2021
Alberto José Carpinteiro Soares
openalex   +1 more source

Autophagy in hepatic adaptation to stress [PDF]

, 2019
Younis Hazari, José Manuel Bravo‐San Pedro, Claudio Hetz, Lorenzo Galluzzi, Guido Kroemer   +4 more
openalex   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Enhancement of Hypoxia-Induced Autophagy via the HIF-1apha/BNIP3 Pathway Promotes Proliferation and Myogenic Differentiation of Aged Skeletal Muscle Satellite Cells. [PDF]

Life (Basel)
Zhou L, Feng C, Lin J, Geng M, Qu D, Xing J, Lin H, Ma X, Nakanishi R, Maeshige N, Kondo H, Fujino H.   +11 more
europepmc   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

The effects of LINC00324 on cell proliferation, migration, and invasion via autophagy in melanoma. [PDF]

Sci Rep
Ma S, Liu C, Ding Y, Li M, Wang M, Feng S.   +5 more
europepmc   +1 more source

Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels [PDF]

, 2014
Yu Zhong, Deanna H. Morris, Lin Jin, Mittul S. Patel, Senthil Karunakaran, You‐Jun Fu, Emily A. Matuszak, Heidi L. Weiss, Brian T. Chait, Qing Jun Wang   +9 more
openalex   +1 more source