Results 81 to 90 of about 286,383 (199)

AUTOPHAGY IN HEPATOCYTES AND ERYTHROPOIETIC CELLS ISOLATED FROM THE TWENTY-ONE DAY OLD RAT EMBRYO [PDF]

, 2001
Attila L. Kovács, Ágnes Telbisz, Abdallah Eldib   +2 more
openalex   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast [PDF]

, 2002
Akiko Kuma, Noboru Mizushima, Naotada Ishihara, Yoshinori Ohsumi   +3 more
openalex   +1 more source

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

Advanced Science, EarlyView.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao, Jun Qi, Fang Li, Haotian Ma, Rui Wang, Xiuyi Yu, Yufei Wang, Sida Qin, Jie Wu, Chen Huang, Hong Ren, Boxiang Zhang   +11 more
wiley   +1 more source

Leaf Senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene [PDF]

, 2002
Hideki Hanaoka, Takeshi Noda, Yumiko Shirano, Tomohiko Kato, Hiroaki Hayashi, Daisuke Shibata, Satoshi Tabata, Yoshinori Ohsumi   +7 more
openalex   +1 more source

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

Advanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang, Shuai Chen, Xiaoqi Xia, Ziwen Tao, Chun Liu, Shanshan Li, Shuo Zhang, Jiali Huang, Lu Xia, Wenqiang Quan, Changqing Yang, Jing Li   +11 more
wiley   +1 more source

Role of LAMP-2 in Lysosome Biogenesis and Autophagy [PDF]

, 2002
Eeva‐Liisa Eskelinen, Anna Lena Illert, Yoshitaka Tanaka, Günter Schwarzmann, Judith Blanz, Kurt Von Figura, Paul Säftig   +6 more
openalex   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Resilient Membranized Coacervates Formed through Spontaneous Wrapping of Heat‐Destabilized Lipid Bilayers around Coacervate Droplets

Advanced Science, EarlyView.
We present a universal way to wrap liposomes around coacervate droplets. Membrane‐enclosed coacervates form when heat‐destabilized liposomes are mixed with coacervates. Membranized coacervates (MCs) can survive pH and ionic strength fluctuations, osmotic stress, and low temperatures.
Sadaf Javed, Evan Spruijt
wiley   +1 more source

Inhibition of Autophagy in Mitotic Animal Cells [PDF]

, 2002
Eeva‐Liisa Eskelinen, Alan R. Prescott, Jennifer Cooper, Saskia M. Brachmann, Lijun Wang, Xiuwen Tang, Jonathan Backer, John M. Lucocq   +7 more
openalex   +1 more source