Results 61 to 70 of about 101,600 (147)

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex

Frontiers in Molecular Neuroscience, 2018
G-protein–coupled receptor (GPCR) heterodimers are new targets for the treatment of schizophrenia. Dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receptors play an important role in neurotransmission and have been implicated in many human ...
Marta Szlachta, Maciej Kuśmider, Paulina Pabian, Joanna Solich, Magdalena Kolasa, Dariusz Żurawek, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka   +7 more
doaj   +1 more source

Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents

Frontiers in Endocrinology
Vasopressin and oxytocin are well known and evolutionarily ancient modulators of social behavior. The distribution and relative densities of vasopressin and oxytocin receptors are known to modulate the sensitivity to these signaling molecules ...
Angela R. Freeman, Angela R. Freeman, Samanta Arenas, Danielle N. Lee, Danielle N. Lee, Bhupinder Singh, Bhupinder Singh, Alexander G. Ophir   +7 more
doaj   +1 more source

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
METTL18 is essential for histidine Nτ‐methylation of proteins, normal embryonic development, iron and lipid metabolism, and hormone signaling pathways that support postnatal growth in mice. The main points of this study are as follows: First, mouse METTL18 catalyzes histidine Nτ‐methylation. Next, Mettl18 KO embryos are significantly smaller than their
Fumiya Kasai, Jun‐Dal Kim, Koichiro Kako, Naoto Muromachi, Takeru Saito, Yao Yuan, Hayase Mizukami, Nana Kishikawa, Kanako Nakamura, Kaori Motomura, Hiroaki Daitoku, Yuuki Imai, Sho Sekiguchi, Kazuhiko Horiguchi, Satoshi Narumi, Masanobu Yamada, Akiyoshi Fukamizu   +16 more
wiley   +1 more source

Determination of the phloem transport pathways and destination of photosynthates in soybean using autoradiography and fluorescent tracer imaging

Plant Signaling & Behavior
Vascular tissues transport water and nutrients in plants, with the phloem distributing photosynthates from source to sink. The direction of phloem transport is determined by the positional relationship between sources and sinks and by vascular ...
Ai Kaiho-Soma, Yuko Kurita, Natsuko I. Kobayashi, Tomoko M. Nakanishi, Keitaro Tanoi   +4 more
doaj   +1 more source

In vitro characterization of [125I]HY-3-24, a selective ligand for the dopamine D3 receptor

Frontiers in Neuroscience
IntroductionDopamine D3 receptor (D3R) ligands have been studied for the possible treatment of neurological and neuropsychiatric disorders. However, selective D3R radioligands for in vitro binding studies have been challenging to identify due to the high
Ji Youn Lee, Ho Young Kim, Paul Martorano, Aladdin Riad, Michelle Taylor, Robert R. Luedtke, Robert H. Mach   +6 more
doaj   +1 more source

Investigating Dietary microRNA Stability and Function Using a Transgenic Milk Model With Unique microRNA Sequences

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Upon ingestion, milk extracellular vesicles (EVs) carrying bioactive cargo such as microRNAs may survive digestion and remain bioactive. Here, milk from wild‐type and transgenic cows expressing unique microRNAs was used to isolate and characterize four EV populations.
Zeinab Husseini, Nathalie Majeau, Ismail Fliss, Abderrahim Benmoussa   +3 more
wiley   +1 more source

11C-Autoradiographs to Image Phloem Loading

Frontiers in Forests and Global Change, 2019
Generally, tree species load photoassimilates passively into the phloem, while herbaceous species load actively. These phloem loading strategies have implications for phloem sugar concentration and growth potential.
Michiel Hubeau, Jens Mincke, Jens Mincke, Christian Vanhove, Anaïs Pasiphaé Gorel, Adeline Fayolle, Jackie Epila, Olivier Leroux, Stefaan Vandenberghe, Kathy Steppe   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, Volume 600, Issue 17, Page 2420-2436, September 2026.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, Volume 13, Issue 49, 3 September 2026.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo

Brazilian Journal of Medical and Biological Research, 1998
It is generally accepted that mitochondria are able to proliferate even in postmitotic cells due to their natural turnover and also to satisfy increased cell energy requirements.
H. Korr, C. Kurz, T.O. Seidler, D. Sommer, C. Schmitz   +4 more
doaj   +1 more source