Results 71 to 80 of about 101,600 (147)

MARBLE: An in vivo MRI marker of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC)

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE‐NC) is common in older adults, yet definitive diagnosis is only possible at autopsy. METHODS This work developed a fully automated in vivo marker of LATE‐NC named MARBLE (MARker of Brain LatE) by applying ...
Mahir Tazwar, Arnold M. Evia, Abdur R. Ridwan, Sue E. Leurgans, Maude Wagner, Alzheimer's Disease Neuroimaging Initiative, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +8 more
wiley   +1 more source

Ultrastructural, autoradiographic and electrophoretic examinations of Chara tomentosa spermiogenesis

Acta Societatis Botanicorum Poloniae, 2014
Ultrastructure of a spermatid nucleus changes many times during spermiogenesis. Condensed chromatin forms irregular clusters during phases I-II, a continuous ring adjacent to a nuclear envelope during phases III-V and a network occupying the whole ...
Maria Kwiatkowska, Andrzej Kaźmierczak, Katarzyna Popłońska   +2 more
doaj   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, Volume 41, Issue 9, Page 2399-2407, September 2026.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

[¹²⁵I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [¹⁸F]Flotaza and [¹²⁵I]IBETA in Postmortem Human Alzheimer’s Disease

Neurology International
Therapeutic antibodies for reducing Aβ plaque load in Alzheimer’s disease (AD) is currently making rapid progress. The diagnostic imaging of Aβ plaque load in AD has been underway and is now used in clinical studies.
Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee   +6 more
doaj   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, Volume 46, Issue 5, Page 1362-1389, September 2026.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Theranostic π Electron‐Stabilized Polymeric Micelles for PET Imaging‐Guided Drug Delivery to Tumors

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanomedicine efficacy is limited by heterogeneous nanoparticle accumulation in tumors. Nuclear imaging offers non‐invasive, patient‐ and lesion‐specific visualization and quantification of nanoparticle uptake. We present a positron emission tomography (PET)‐imageable micelle platform for direct quantification of nanoparticle accumulation and ...
Alec Wang, Alexandru Florea, Jan‐Niklas May, Zaheer Ahmed, Karolin Roemhild, Thomas Hansen, Rahaf Mihyar, Armin Azadkhah Shalmani, Laura Schäfer, Karolin Becker, Masoud Sadeghzadeh, Eva M. Buhl, Sven Thoröe‐Boveleth, Susanne Lütje, Agnieszka Morgenroth, Fabian Kiessling, Jochen Maurer, Josbert M. Metselaar, Yang Shi, Felix M. Mottaghy, Quim Peña, Twan Lammers   +21 more
wiley   +1 more source

A Bayesian Hierarchical Approach to Quasi-Replicate Dataset Modelling

Mathematics
It is very common for multiple experiments to be conducted under non-identical but similar conditions, perhaps because of implementation errors, natural variability in experimental material, or gradual drifting of experimental conditions. In the extremes
Hassan M. Aljohani, Robert G. Aykroyd
doaj   +1 more source

Complementarity of radioautographic and immunohistochemical techniques for localizing neuroreceptors at the light and electron microscopy level

Brazilian Journal of Medical and Biological Research, 1998
To assess relationships between neuropeptide-binding sites and receptor proteins in rat brain, the distribution of radioautographically labeled somatostatin and neurotensin-binding sites was compared to that of immunolabeled sst2A and NTRH receptor ...
Beaudet A.
doaj  

A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy

Pharmaceuticals
Background: Boron Neutron Capture Therapy (BNCT) is a promising cancer treatment that combines tumor-selective boron delivery agents with thermal neutrons to kill cancer cells while sparing normal tissue.
Daniela Imperio, Ian Postuma, Salvatore Villani, Erika Del Grosso, Laura Cansolino, Cinzia Ferrari, Silvia Fallarini, Silva Bortolussi, Luigi Panza   +8 more
doaj   +1 more source