Results 91 to 100 of about 46,029 (270)

The societal economic burden of autosomal dominant polycystic kidney disease in the United States

BMC Health Services Research, 2020
Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited kidney diseases characterized by progressive development of renal cysts and numerous extra-renal manifestations, eventually leading to kidney failure ...
M. Cloutier, A. Manceur, A. Guerin, M. Aigbogun, Dorothee Oberdhan, M. Gauthier-Loiselle   +5 more
semanticscholar   +1 more source

Autosomal-dominante polyzystische Nierenerkrankung: Neue therapeutische Ansätze [PDF]

, 2018
Zusammenfassung: Die autosomal-dominante polyzystische Nierenerkrankung ("autosomal dominant polycystic kidney disease", ADPKD) ist die häufigste genetische Nierenerkrankung, sie betrifft weltweit etwa 6Mio. Menschen.
Poster, D., Serra, A.L., Wüthrich, R.P.
core  

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

British Journal of Pharmacology, Volume 182, Issue 19, Page 4611-4624, October 2025.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen   +2 more
wiley   +1 more source

TNF-α blockade is ineffective in animal models of established polycystic kidney disease [PDF]

, 2013
BACKGROUND: Given the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need for novel, safe and effective treatments for the disorder.
Jeffrey Roix, Saurabh Saha
core   +2 more sources

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Automatic Measurement of Kidney and Liver Volumes from MR Images of Patients Affected by Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology, 2019
BACKGROUND The formation and growth of cysts in kidneys, and often liver, in autosomal dominant polycystic kidney disease (ADPKD) cause progressive increases in total kidney volume (TKV) and liver volume (TLV). Laborious and time-consuming manual tracing
M. V. van Gastel, Marie E. Edwards, V. Torres, B. Erickson, R. Gansevoort, T. Kline   +5 more
semanticscholar   +1 more source

Health-related quality of life across all stages of autosomal dominant polycystic kidney disease [PDF]

, 2016
Background. A limited number of studies have assessed health related quality of life (HRQoL) in autosomal dominant polycystic kidney disease (ADPKD). Results to date have been conflicting and studies have generally focused on patients with later stages ...
Dieperink, Hans, Eklund, Oskar, Eriksson, Daniel, Honkanen, Eero, Karlsson, Linda, Lundberg, Johan, Melin, Jan, Selvig, Kristian   +7 more
core   +2 more sources

Arterialization of the Portal Vein: A Potentially Graft‐Saving Strategy to Optimize Veno‐Arterial Inflow in Liver Transplantation

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Introduction The dual vascular inflow of liver grafts in liver transplantation (LT) is increasingly recognized as crucial to achieving adequate graft function in deceased donor LT (DDLT). Portal hyperperfusion is the most common, leading to decreased intrahepatic adenosine and arterial vasoconstriction via the hepatic artery buffer response ...
Teresa Diago Uso, Chase J. Wehrle, Giuseppe Iuppa, Luca Del Prete, Sangeeta Satish, Masato Fujiki, Federico Aucejo, Koji Hashimoto, Charles Miller, Luis Campos, Cristiano Quintini   +10 more
wiley   +1 more source

Renal Transplantation in Autosomal Dominant Polycystic Kidney Disease [PDF]

European Medical Journal Nephrology, 2015
Autosomal dominant polycystic kidney disease (ADPKD) affects approximately 1 in 1,000 people in the general population. The natural history of ADPKD includes the progression of chronic kidney disease to end-stage renal disease (ESRD) in a large ...
Andrzej Kulesza, Longin Niemczyk, Mariusz Niemczyk   +2 more
doaj  

Disease causing property analyzation of variants in 12 Chinese families with polycystic kidney disease

Molecular Genetics & Genomic Medicine, 2020
Background Polycystic kidney disease (PKD) is an inherited disease that is life‐threatening. Multiple cysts are present in the bilateral kidneys of PKD patients.
Kexian Dong, Xiaogang Liu, Xueyuan Jia, Huanhuan Miao, Wei Ji, Jie Wu, Yun Huang, Lidan Xu, Xuelong Zhang, Hui Su, Guohua Ji, Peng Liu, Rongwei Guan, Jing Bai, Songbin Fu, Xianli Zhou, Wenjing Sun   +16 more
doaj   +1 more source