Results 91 to 100 of about 149,259 (318)

Effect of Heterogeneous Mixing and Vaccination on the Dynamics of Anthelmintic Resistance: A Nested Model [PDF]

Sabatelli L (2010) Effect of Heterogeneous Mixing and Vaccination on the Dynamics of Anthelmintic Resistance: A Nested Model. PLoS ONE 5(5): e10686. doi:10.1371/journal.pone.0010686, 2010
Anthelmintic resistance is a major threat to current measures for helminth control in humans and animals. The introduction of anthelmintic vaccines, as a complement to or replacement for drug treatments, has been advocated as a preventive measure. Here, a computer-based simulation, tracking the dynamics of hosts, parasites and parasite-genes, shows ...
arxiv   +1 more source

Index cases of intracranial aneurysms in autosomal dominant polycystic kidney disease: longitudinal experience from a single renal transplantation centre

ANZ Journal of Surgery, EarlyView.
Abstract Background The prevalence of intracranial aneurysms (ICAs) is higher in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. This extrarenal manifestation carries significant mortality and morbidity risks.
Joel Ern Zher Chan, Kate S. Olakkengil, Shantanu Bhattacharjya, Santosh Antony Olakkengil   +3 more
wiley   +1 more source

Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]

, 2006
PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E., Moon, D.J., Obara, T., Ong, A.C.M., Streets, A.J.   +4 more
core   +2 more sources

Relevance of ultrasound examination in general practice. A case report of a patient with autosomal dominant polycystic kidney disease

Journal of Ultrasonography, 2013
Autosomal dominant polycystic kidney disease is a genetic disorder which results in the development of multiple cysts in the kidneys and other parenchymal organs. The two genes in which mutations are known to cause autosomal dominant polycystic kidney
Izabela Cwojdzińska-Jankowska, Anna Plewa   +1 more
doaj  

Tuberous sclerosis complex—varied presentations in family clusters

Indian Journal of Dermatology, 2023
Tuberous sclerosis complex (TSC) is a disease of varying presentations characterised by the presence of multiple hamartomas in various organ systems in the body.
Ayush Sopori, Seema Sharma, Kavya Sharma, Milap Sharma   +3 more
doaj   +1 more source

The Pathogenesis of Autosomal Dominant Polycystic Kidney Disease [PDF]

Nephron Experimental Nephrology, 2006
In individuals with autosomal dominant polycystic kidney disease (ADPKD), renal function deteriorates as the kidneys become replaced by multitudes of fluid-filled cysts. Although the PKD genes were identified a decade ago, the pathway(s) leading from mutation to disease remain the subject of intense investigation.
openaire   +3 more sources

Hypertension in autosomal-dominant polycystic kidney disease (ADPKD) [PDF]

Clinical Kidney Journal, 2013
Cardiovascular (CV) complications are the major cause of death in autosomal-dominant polycystic kidney disease (ADPKD) patients. Hypertension is common in these patients even before the onset of renal insufficiency. Blood pressure (BP) elevation is a key factor in patient outcome, mainly owing to the high prevalence of target organ damage together with
Roser Torra, Laia Sans-Atxer, Patricia Fernández-Llama   +2 more
openaire   +5 more sources

Short (2‐Hour) Non‐Oxygenated End‐Ischemic Hypothermic Perfusion Versus Cold Storage in the Setting of Renal Transplantation

Artificial Organs, Volume 49, Issue 5, Page 831-841, May 2025.
EI‐HMP enhances urine output and reduces ICU stay in kidney transplant patients, particularly in ECD grafts, but does not significantly impact long‐term survival or dialysis avoidance. These short‐term benefits suggest EI‐HMP may improve early recovery, although its long‐term efficacy requires further investigation through randomized controlled trials.
Franco Ruberto, Quirino Lai, Mario Piazzolla, Luca Poli, Veronica Zullino, Giulia Diamantini, Matteo Brisciani, Francesco Giovanardi, Fabio Melandro, Silvia Quaresima, Massimo Rossi, Manuela Garofalo, Francesco Pugliese   +12 more
wiley   +1 more source

A novel PKD1 variant demonstrates a disease-modifying role in trans with a truncating PKD1 mutation in patients with Autosomal Dominant Polycystic Kidney Disease [PDF]

, 2015
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common form of Polycystic Kidney Disease (PKD) and occurs at a frequency of 1/800 to 1/1000 affecting all ethnic groups worldwide.
Al-Mulla, Fahd, Ali, Hamad, Harris, Peter, Hussain, Naser, Kehinde, Elijah, Naim, Medhat, Seaburg, Lauren, Sundsbak, Jamie, Zayed, Mohamed   +8 more
core  

Renal replacement therapy in ADPKD patients : a 25-year survey based on the Catalan registry [PDF]

, 2013
Background: Some 7-10% of patients on replacement renal therapy (RRT) are receiving it because of autosomal dominant polycystic kidney disease (ADPKD). The age at initiation of RRT is expected to increase over time.
Arcos, Emma, Ars Criach, Elisabet, Ballarín Castan, José Aurelio, Cabezuelo, Juan, Comas, Jordi, Díaz Gómez, Joan Manuel, Martínez, Víctor, Muray, Salomé, Torra Balcells, Roser   +8 more
core   +1 more source