Results 101 to 110 of about 43,436 (236)

Global microRNA profiling in human urinary exosomes reveals novel disease biomarkers and cellular pathways for autosomal dominant polycystic kidney disease.

Kidney International, 2020
MicroRNAs (miRNAs) play an important role in regulating gene expression in health and disease but their role in modifying disease expression in Autosomal Dominant Polycystic Kidney Disease (ADPKD) remains uncertain.
T. Magayr, Xuewen Song, A. Streets, L. Vergoz, Lijun Chang, M. Valluru, H. Yap, M. Lannoy, A. Haghighi, R. Simms, F. Tam, Y. Pei, A. Ong   +12 more
semanticscholar   +1 more source

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, Volume 7, Issue 2, April 2026.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

Hepatic Cyst Infection During Use of the Somatostatin Analog Lanreotide in Autosomal Dominant Polycystic Kidney Disease: An Interim Analysis of the Randomized Open-Label Multicenter DIPAK-1 Study [PDF]

, 2017
Introduction and Aims: The DIPAK-1 Study investigates the reno- and hepatoprotective efficacy of the somatostatin analog lanreotide compared with standard care in patients with later stage autosomal dominant polycystic kidney disease (ADPKD). During this
Casteleijn, E. (Eric), de Fijter, J.W. (Johan W.), Drenth, J.P.H., Drenth, J.P.H. (Joost), D’Agnolo, H.M.A. (Hedwig M. A.), Fijter, J.W. (Johan) de, Gansevoort, R.T., Gansevoort, R.T. (Ron), Lantinga, M.A. (Marten A.), Meijer, E. (Esther), Messchendorp, A.L. (A. Lianne), Peters, D. (Dorien), Peters, D.J.M. (Dorien J.M.), Salih, M. (Mahdi), Soonawala, D. (Darius), Spithoven, E.M. (Edwin), Visser, F.W. (Folkert), Wetzels, J.F.M. (Jack F. M.), Wetzels, J.F.M. (Jack), Zietse, R., Zietse, R. (Bob)   +20 more
core   +1 more source

Automatic Measurement of Kidney and Liver Volumes from MR Images of Patients Affected by Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology, 2019
BACKGROUND The formation and growth of cysts in kidneys, and often liver, in autosomal dominant polycystic kidney disease (ADPKD) cause progressive increases in total kidney volume (TKV) and liver volume (TLV). Laborious and time-consuming manual tracing
M. V. van Gastel, Marie E. Edwards, V. Torres, B. Erickson, R. Gansevoort, T. Kline   +5 more
semanticscholar   +1 more source

A Retrospective Cross‐Sectional Study of 142 Patients in a Multidisciplinary Tuberous Sclerosis Clinic

Clinical Genetics, Volume 109, Issue 4, Page 697-706, April 2026.
We found key differences between tuberous sclerosis patients with TSC1 and TSC2 variants. Patients carrying TSC2 variants had more severe and earlier‐onset symptoms. We also identified two distinct clinical subgroups which follow different disease courses: one characterized by predominant renal involvement and the other by more pronounced neurological ...
Hila Weisblum Neuman, Sara Via Dorembus, Omer Shlomovitz, Shoshana Greenberger, Einat Lahav, Sharon Mini‐Goldberger, Michal Tzadok   +6 more
wiley   +1 more source

Intracranial aneurysms in autosomal dominant polycystic kidney disease [PDF]

Kosin Medical Journal
Background The incidence of intracranial aneurysms (ICA) is high in patients with autosomal dominant polycystic kidney disease (ADPKD). However, little is known regarding the optimal screening and treatment methods for ICA.
Jung Hyun Park
doaj   +1 more source

New mutations in the gene in Czech population with autosomal dominant polycystic kidney disease [PDF]

, 2009
Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. The disease is caused by mutations of the PKD1 (affecting roughly 85% of ADPKD patients) and PKD2 (affecting roughly 14% of ADPKD patients) genes,
Merta Miroslav, Lnenicka Petr, Kebrdlova Vera, Svobodova Stanislava, Reiterova Jana, Stekrova Jitka, Viklicky Ondrej, Kohoutova Milada   +7 more
core   +2 more sources

Altered functional interactions between CFTR disease mutants ΔF508 and G551D and the protein kinase A catalytic subunit

The Journal of Physiology, Volume 604, Issue 8, Page 3344-3362, 15 April 2026.
Abstract figure legend Pathogenic mutations ΔF508 and G551D of the cystic fibrosis transmembrane conductance regulator (CFTR) channel alter its interactions with protein kinase A (PKA). Top left, for both mutants, but not for wild‐type (WT) CFTR, non‐catalytic stimulation of channel activity by PKA is larger in the presence of N6‐(2‐phenylethyl)‐ATP (P‐
Olivér Závoti, Márton A. Simon, László Csanády   +2 more
wiley   +1 more source

Autopsy Report with Clinical and Pathophysiologic Discussion of Autosomal Dominant Adult Polycystic Kidney Disease

Case Reports in Urology, 2014
The average weight of a kidney is approximately 135 gm, measuring on average 10 × 6 × 4 cm. In hereditary conditions, autosomal dominant and autosomal recessive polycystic kidney disease, the shape, size, and the weight can be significantly abnormal ...
Anup Hazra, Richard Siderits, Cheryl Rimmer, Noah Rolleri   +3 more
doaj   +1 more source

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. [PDF]

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 ...
Bourgeois, Bryan C, Kruger, Samantha L, Shillingford, Jonathan M, Torres, Jacob, Weimbs, Thomas   +4 more
core   +1 more source