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Computation of multilocus prior probability of autozygosity for complex inbred pedigrees [PDF]

Genetic Epidemiology, 1997
Homozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes a simple yet powerful method for computing the prior multilocus autozygosity probability for ...
S W Guo
exaly   +3 more sources

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Runs of homozygosity reveal genome‐wide autozygosity in Italian sheep breeds

Animal Genetics, 2018
SummaryThe availability of dense single nucleotide polymorphism (SNP) assays allows for the determination of autozygous segments based on runs of consecutive homozygous genotypes (ROH). The aim of the present study was to investigate the occurrence and distribution of ROH in 21 Italian sheep breeds using medium‐density SNP genotypes in order to ...
Mastrangelo, S., Ciani, E., Sardina, M. T., Sottile, G., Pilla, F., Portolano, B.   +5 more
openaire   +3 more sources

Genomic metrics of individual autozygosity, applied to a cattle population

2010
High throughput genotyping technology provides information about a large number of genetic markers roughly evenly spread across the genome. Levels of individual homozygosity and homozygous segments (runs of homozygosity) provide information about levels of inbreeding of animals.
Sölkner, Johann, Ferencakovic, Maja, Gredler, Birgit, Curik, Ino   +3 more
openaire   +2 more sources

A Genome-Wide Investigation of Autozygosity and Breast Cancer Risk

2011
Abstract : Longs segments ( 1 megabase) of homozygous DNA are common in the genomes of outbred human populations. Several lines of research indicate that elevated genome-wide homozygosity and runs of homozygosity (RoH) at specific loci may increase breast cancer risk. In this project, we determine if genome-wide RoH content and individual RoHs are more
openaire   +1 more source

Associations of autozygosity with economic important traits in a cross of Eurasian pigs

Journal of Genetics and Genomics, 2023
Lin Tao, Li-Gang Wang, Adeniyi C. Adeola, Long-Chao Zhang, Lian-Wei Li, Qing-Long Li, Dao-Ji Cen, Chen Yan, Zhan-Shan Ma, Li-Xian Wang, Hai-Bing Xie, Ya-Ping Zhang   +11 more
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Autozygosity

2022
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Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.

2013
PUBLISHED
MORRIS, DEREK, GILL, MICHAEL, CORVIN, AIDEN PETER   +2 more
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Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample

Behavior Genetics, 2022
Arpana Agrawal, Matthew C Keller, Emma C Johnson   +2 more
exaly  

Whole Exome Sequencing, homozygosity, autozygosity

Journal of Biotechnology, 2014
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. Autosomal Recessive Conditions and Autozygosity Mapping

2012
Colin A. Johnson, Eamonn R. Maher
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