Results 141 to 150 of about 2,131 (168)

Assessment of genome-wide genetic variability and population divergence of four native Turkish sheep breeds. [PDF]

Mamm Genome
Karslı BA, Demir E, Bilginer U, Karslı T, Kaya S, Doğru H, Kara I, Atmaca V, Kaşıkçı D, Koçak S, Yağcı S, Balcıoğlu MS, Lasagna E, Gülyüz F.   +13 more
europepmc   +1 more source

Parental Consanguinity and Family History in Relation to Psoriasis and the Role of Sex: A Case-Control Study.

Hum Hered
AlKhas AN, Ziyab AH.
europepmc   +1 more source

Proteomic and clinical impact of human knockouts in British South Asians

Carrasco Zanini J, Pietzner M, Koprulu M, Zoodsma M, Williamson A, Hunt KA, Manolias A, Walter K, Genes & Health Industry Consortium, Genes & Health Research Team, Martin HC, Finer S, van Heel DA, Langenberg C.   +13 more
europepmc   +1 more source

Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis [PDF]

Cancers, 2020
Global autozygosity quantifies the genome-wide levels of homozygous and heterozygous variants. It is the signature of non-random reproduction, though it can also be driven by other factors, and has been used to assess risk in various diseases.
Limin Jiang, Fei Guo, Jijun Tang
exaly   +5 more sources

Association Between Autozygosity and Major Depression: Stratification Due to Religious Assortment [PDF]

Behavior Genetics, 2013
The effects of inbreeding on the health of offspring can be studied by measuring genome-wide autozygosity as the proportion of the genome in runs of homozygosity (
Abdel Abdellaoui, Jouke-Jan Hottenga, Xiangjun Xiao   +2 more
exaly   +6 more sources

Computation of multilocus prior probability of autozygosity for complex inbred pedigrees [PDF]

Genetic Epidemiology, 1997
Homozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes
Sun-Wei Guo, S W Guo
exaly   +5 more sources

Autozygosity Mapping with Exome Sequence Data [PDF]

Human Mutation, 2013
Autozygosity mapping is a powerful method for the identification of recessively inherited disease genes using small inbred families. Typically, microarray SNP genotype data are first used to identify autozygous regions as extended runs of homozygous ...
Ian M Carr, Sanjeev Bhaskar, Mohammed A Aldahmesh   +2 more
exaly   +4 more sources

Estimating the human mutation rate using autozygosity in a founder population [PDF]

Nature Genetics, 2012
Knowledge of the rate and pattern of new mutation is critical to the understanding of human disease and evolution. We used extensive autozygosity in a genealogically well-defined population of Hutterites to estimate the human sequence mutation rate over ...
Catarina D Campbell, Jessica X Chong, Arthur Ko   +2 more
exaly   +8 more sources

RZooRoH: An R package to characterize individual genomic autozygosity and identify homozygous‐by‐descent segments [PDF]

Methods in Ecology and Evolution, 2019
these are two files used to test the RZooRoH package in the manuscript: RZooRoH: an R package to characterize genomic autozygosity and identify homozygous-by-descent segments A.R. Bertrand, N.K. Kadri, L. Flori, M. Gautier and T.
Amandine R Bertrand, Naveen Kumar Kadri, Laurence Flori   +2 more
exaly   +2 more sources