Results 91 to 100 of about 47,682 (268)

Additional file 1 of Viral community-wide auxiliary metabolic genes differ by lifestyles, habitats, and hosts

, 2022
Additional file 1: Fig. S1. Geographic distributions of viruses. Fig. S2. Comparisons of the genomic properties between lytic and temperate viruses in the rarefied completeness-filtered dataset. Fig. S3. Comparisons of the functional diversities and compositions of AMGs between lytic and temperate viruses in three datasets. Fig. S4. Lifestyle-dependent
Luo, Xiao-Qing, Wang, Pandeng, Li, Jia-Ling, Ahmad, Manzoor, Duan, Li, Yin, Ling-Zi, Deng, Qi-Qi, Fang, Bao-Zhu, Li, Shan-Hui, Li, Wen-Jun   +9 more
openaire   +1 more source

Host-linked soil viral ecology along a permafrost thaw gradient [PDF]

, 2018
Climate change threatens to release abundant carbon that is sequestered at high latitudes, but the constraints on microbial metabolisms that mediate the release of methane and carbon dioxide are poorly understood1,2,3,4,5,6,7.
Bolduc, Benjamin, Boyd, Joel A., Brum, Jennifer R., Chanton, Jeffrey P., Crill, Patrick M., Emerson, Joanne B., Frolking, Stephen E., Hodgkins, Suzanne B., Jang, Ho Bin, Li, Changsheng, Naas, Adrian E., Pope, Phillip B., Rich, Virginia I., Roux, Simon, Saleska, Scott R., Singleton, Caitlin M., Solden, Lindsey M., Sullivan, Matthew B., Trubl, Gareth, Tyson, Gene W., Wilson, Rachel M., Woodcroft, Ben J., Wrighton, Kelly C.   +22 more
core   +1 more source

(Per)chlorate-reducing bacteria can utilize aerobic and anaerobic pathways of aromatic degradation with (per)chlorate as an electron acceptor. [PDF]

, 2015
UnlabelledThe pathways involved in aromatic compound oxidation under perchlorate and chlorate [collectively known as (per)chlorate]-reducing conditions are poorly understood.
Bauer, Stefan, Carlström, Charlotte I, Clark, Iain C, Coates, John D, Iavarone, Anthony T, Loutey, Dana, Lucas, Lauren, Rohde, Robert A   +7 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Genome Sequences of the First Phages Infecting Limnohabitans Reveal Their Global Distribution and Metabolic Potential

Microorganisms
Bacteriophages (phages) are one of the critical biotic drivers of prokaryotic community dynamics, functions, and evolution. Despite their importance in aquatic ecosystems, very few phages have been isolated from freshwater lakes, hampering our ...
Boxuan Deng, Raoqiong Che, Pinxin Zhu, Yongxia Wang, Zhiying Li, Shiying Zhang, Wei Xiao   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Yaravirus brasiliense genomic structure analysis and its possible influence on the metabolism [PDF]

Genetics and Molecular Biology
Here we analyze the Yaravirus brasiliense, an amoeba-infecting 80-nm-sized virus with a 45-kbp dsDNA, using structural molecular modeling. Almost all of its 74 genes were previously identified as ORFans.
Ana Karoline Nunes-Alves, Jônatas Santos Abrahão, Sávio Torres de Farias   +2 more
doaj   +1 more source

Niche differentiation is spatially and temporally regulated in the rhizosphere. [PDF]

, 2020
The rhizosphere is a hotspot for microbial carbon transformations, and is the entry point for root polysaccharides and polymeric carbohydrates that are important precursors to soil organic matter (SOM).
Banfield, Jillian F, Brodie, Eoin L, Firestone, Mary K, Karaoz, Ulas, Malmstrom, Rex R, Nuccio, Erin E, Pett-Ridge, Jennifer, Starr, Evan, Tringe, Susannah G, Woyke, Tanja, Zhou, Jizhong   +10 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Role of the Bifunctional Aminoacyl-tRNA Synthetase EPRS in Human Disease [PDF]

, 2020
Aminoacyl-tRNA synthetases (AARS) are a class of enzymes that catalyze the charging of tRNAs with cognate amino acids, a critical step that contributes to the fidelity of protein synthesis.
Kudlapur, Nathan
core