Results 101 to 110 of about 47,682 (268)

ADP-dependent Phosphofructokinases in Mesophilic and Thermophilic Methanogenic Archaea [PDF]

, 2001
Phosphofructokinase (PFK) is a key enzyme of the glycolytic pathway in all domains of life. Two related PFKs, ATP-dependent and PPi-dependent PFK, have been distinguished in bacteria and eucarya, as well as in some archaea.
Verhees, C.H., Tuininga, J.E., Kengen, S.W.M., Stams, A.J.M., Oost, J., van der, Vos, W.M., de   +5 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

New viral biogeochemical roles revealed through metagenomic analysis of Lake Baikal

Microbiome, 2020
Background Lake Baikal is the largest body of liquid freshwater on Earth. Previous studies have described the microbial composition of this habitat, but the viral communities from this ecosystem have not been characterized in detail.
F. H. Coutinho, P. J. Cabello-Yeves, R. Gonzalez-Serrano, R. Rosselli, M. López-Pérez, T. I. Zemskaya, A. S. Zakharenko, V. G. Ivanov, F. Rodriguez-Valera   +8 more
doaj   +1 more source

A Taxonomy of Causality-Based Biological Properties [PDF]

, 2010
We formally characterize a set of causality-based properties of metabolic networks. This set of properties aims at making precise several notions on the production of metabolites, which are familiar in the biologists' terminology.
A. Coletta, A. Phillips, A. Regev, A. Regev, Andrea Bracciali, B. Shargel, B.J. Yu, C. Baral, C. Bodei, C. Bodei, C. Priami, C. Priami, C. Priami, C.H. Schilling, Chiara Bodei, D.A. Fell, Davide Chiarugi, Emanuela Merelli, F. Nielson, F. Nielson, F. Orosz, G.T. Gillespie, H Kitano, H. Kitano, H. Kitano, H. Pilegaard, H. Pilegaard, H. Yu, J. Stelling, J. Thykaer, L. Cardelli, L. Cardelli, M. Curti, N. Chabrier, Paola Quaglia, R. Albert, R. Gori, R. Gori, R. Milner, R.A. Gatenby, R.G. Clyde, Roberta Gori, S. Eker, S. Fatumo, S. Gerdes, S. Klamt, S. Schuster, S. Schuster, S.S Gambhir, U. Alon, V. Danos, V. Danos, Y-K. Oh   +52 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Healthy and moribund Zhikong scallops (Chlamys farreri) developed different viral communities during a mass mortality event

mSystems
Viral assemblages of scallops are still relatively unknown. Here, metagenomic analysis was used to study virus communities in the gut of scallops to establish the first scallop virome data set (SVD); this contains 7,447 viral operational taxonomic units.
Jiaxiang Li, Kaiyang Zheng, Wei Ding, Longfei Lu, Yantao Liang, Yao Xiong, Zhongcheng Wei, Chen Gao, Yue Su, Ziyue Wang, Xin Chen, Zhenmin Bao, Xiaoli Hu, Andrew McMinn, Min Wang   +14 more
doaj   +1 more source

A fast algorithm for detecting gene-gene interactions in genome-wide association studies [PDF]

, 2014
With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches.
Li, Jiahan, Li, Runze, Wu, Rongling, Zhong, Wei   +3 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Insights into the Composition and Function of Virus Communities During Acetic Acid Fermentation of Shanxi Aged Vinegar

Foods
Viruses play a regulatory role in microbial ecology. Traditional fermented foods have complex fermentation environments with abundant viral participation, yet current research on viral communities in fermented foods remains insufficient.
Zhen Yu, Huizi Zhao, Tingting Ma, Xujiao Zhang, Yufeng Yan, Yini Zhu, Yongjian Yu   +6 more
doaj   +1 more source