Results 131 to 140 of about 5,689,842 (310)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Multiple imputation using auxiliary imputation variables that only predict missingness can increase bias due to data missing not at random

BMC Medical Research Methodology
Background Epidemiological and clinical studies often have missing data, frequently analysed using multiple imputation (MI). In general, MI estimates will be biased if data are missing not at random (MNAR).
Elinor Curnow, Rosie P. Cornish, Jon E. Heron, James R. Carpenter, Kate Tilling   +4 more
doaj   +1 more source

Transitivity in flux: the role of Voice and v in the syntax of Dutch (change-of-)location verbs

Glossa
Dutch location and change-of-location verbs exhibit seemingly contradictory properties, with characteristics of transitives and unaccusatives mixed.
Irina Burukina, Marcel den Dikken, Maria Polinsky   +2 more
doaj   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Efficient Multi-Task Auxiliary Learning: Selecting Auxiliary Data by Feature Similarity [PDF]

Proceedings of the 2021 Conference on Empirical Methods in Natural Language Processing, 2021
Po-Nien Kung, Sheng-Siang Yin, Yi-Cheng Chen, Tse-Hsuan Yang, Yun-Nung Chen   +4 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission

, 2015
Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 4/18/15Official website of the Connecticut Judicial Selection Commission ...

core  

Pulaski Day Parade Polish Women's Auxiliary Post 121

, 1965
Group photograph of the Women's Auxiliary Post 121 during the Pulaski Day ...

core   +1 more source

Esse and sta : auxiliary selection in the Aquilan dialect

Dialectologia: revista electrònica, 2013
This paper presents data on auxiliary selection in Aquilan dialect. It focuses on the two auxiliary verbs esse and sta, which respectively express a permanent and temporary property that holds for a given predicate. The goals of the paper are twofold. A first goal is to offer data on the distribution of these auxiliary verbs, filling an empirical void ...
openaire   +4 more sources

On variable auxiliary selection in Western Europe

Linguistic Research, 2015
Donohue, Cathryn. 2015. On variable auxiliary selection in Western Europe. Linguistic Research 32(2), 469-480. A number of Western European languages use two different auxiliary verbs when forming the perfect aspect with monadic verbs, roughly corresponding to have and be. While such a split is cross-linguistically rare, various studies have shown that
openaire   +3 more sources