Results 81 to 90 of about 4,094,957 (302)

An optimal tropospheric tomography approach with the support of an auxiliary area

Annals of Geophysics, 2018
. Among most current tropospheric tomography studies, only the signals crossing out from the top boundary of the tomographic area are used for reconstructing the three-dimensional water vapour field, while signals penetrating from the side faces of the ...
Qingzhi Zhao, Yibin Yao, Wanqiang Yao, Pengfei Xia   +3 more
semanticscholar   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Automatic Planning Approach of Auxiliary Clamping Points of Rapid Fixture in Thin-Walled Parts

, 2010
In order to solve the deformation of thin-walled parts when fixed by fixtures in the environment of examination, transport, welding, assembly and demonstration, the paper is based on automatic planning approach of main champing points in Rapid Fixture ...
Qing Xi Hu, Ting Wen
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Auxiliary strobe lights improve train visibility

, 2019
The inattentiveness of road users during their approach towards passive railway crossings represents a major threat for level crossing safety. This paper presents an auxiliary strobe light system installed in train in addition to the already existing ...
Dressler, Annika, Lehtonen, Esko; id_orcid, Mesimäki, Johannes; id_orcid, Bialinska, Katrin, Grippenkoven, Jan, Virtanen, Ari, Silla, Anne; id_orcid   +6 more
core  

Improvement of auxiliary mechanization operations management at an open-pit coal mine based on a process approach with ICT support

, 2013
This paper presents a modern systematic approach to the improvement of the management system for auxiliary mechanization operations at an open-pit coal mine. The approach is based on an integrated model (IM) of business processes and information systems (
Mitrović, Radivoje, Pantelić, S.D., Jovanović, D., Stošić, D., Dimitrijević, S., Ivanović, Gradimir   +5 more
core   +1 more source

DRHC synthesis for simultaneous tracking and formation of nonhomogeneous multi-agents with time-varying communication topology

International Journal of Advanced Robotic Systems, 2017
The synthesis approach of distributed receding horizon control is studied for the simultaneous tracking and formation problem of nonhomogeneous multi-agents. Different from the existing works, the communication topology between multi-agents is allowed to
Peng Wang, Xinxi Feng, Weihua Li, Wangsheng Yu   +3 more
doaj   +1 more source