Results 91 to 100 of about 334,818 (282)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Comparative study of fractional Newell–Whitehead–Segel equation using optimal auxiliary function method and a novel iterative approach

AIP Advances
This research explores the solution of the time-fractional Newell–Whitehead–Segel equation using two separate methods: the optimal auxiliary function method and a new iterative method.
Xiao Xin, Ibrar khan, Abdul Hamid Ganie, Ali Akgül, Ebenezer Bonyah, Dowlath Fathima, Badria Almaz Ali Yousif   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fractional view analytical analysis of generalized regularized long wave equation

Open Physics
In this research study, we focus on the generalized regularized long wave equation and the modified regularized long wave equation, which play pivotal roles in characterizing plasma waves in oceans and ion acoustic waves in shallow water, a domain deeply
Ganie Abdul Hamid, Yasmin Humaira, Alderremy Aisha A., Alshehry Azzh Saad, Aly Shaban   +4 more
doaj   +1 more source

Diagnostic accuracy of three placement sites for the cold test in subjects amongst different age groups

BMC Oral Health, 2019
Background The cold test is a specific test of pulp sensitivity and is part of the endodontic diagnosis. The aim of this study was to identify the diagnostic accuracy including sensitivity, specificity, accuracy, positive predictive value and negative ...
Brenda Eréndida Castillo-Silva, Jorge Alejandro Alegría-Torres, Gabriel Alejandro Martínez-Castañón, Carlo Eduardo Medina-Solís, Norma Verónica Zavala-Alonso, Nereyda Niño-Martínez, Eva Concepción Aguirre-López, Nuria Patiño-Marín   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analytical Method for Determining the Viscosity Index of Engine Lubricating Oils

Energies
This paper proposes a simple analytical method for determining the viscosity index (VI) that effectively aligns with results obtained from the applicable standards.
Leszek Chybowski, Marcin Szczepanek, Konrad Ćwirko, Konrad Marosek   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Early auroral photography and observations at the Sodankylä Geophysical Observatory in Finland, 1927–1929 [PDF]

History of Geo- and Space Sciences
In Finland, auroral photography started in 1927 at the Sodankylä Geophysical Observatory (SGO) with the initiative of famous Norwegian scientist Carl Störmer. In less than 2 years about 600 photographs of auroras were taken at Sodankylä.
H. Nevanlinna, E. I. Tanskanen
doaj   +1 more source

Hierarchical Encoder with Auxiliary Supervision for Neural Table-to-Text Generation: Learning Better Representation for Tables

Proceedings of the AAAI Conference on Artificial Intelligence, 2019
Generating natural language descriptions for the structured tables which consist of multiple attribute-value tuples is a convenient way to help people to understand the tables. Most neural table-to-text models are based on the encoder-decoder framework. However, it is hard for a vanilla encoder to learn the accurate semantic representation of a complex
Tianyu Liu, Fuli Luo, Qiaolin Xia, Shuming Ma, Baobao Chang, Zhifang Sui   +5 more
openaire   +2 more sources