Synthesis and Evaluation of Cytostatic and Antiviral Activities of 3′ and 4′-Avarone Derivatives
Antiviral Chemistry and Chemotherapy, 1991 A series of 3′ and 4′-substituted avarone derivatives were synthesized and tested in culture systems as antitumour and antiviral agents in comparison to avarol and avarone. 3′-alkylamino derivatives showed potent cytostatic activities against murine L1210 and human B (Raji) and T (C8166, H9) lymphoblast cells (ID50 range 1.7–3.7 μm).
A De Giulio +7 more
openaire +5 more sources
The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives [PDF]
FEBS Letters, 1990 We have analyzed the effects of several natural compounds related to avarols and avarones on the catalytic functions of human immunodeficiency virus type 1 (HIV‐1) reverse transcriptase (RT). The most potent substances, designated as avarone A,B and E and avarol F, inhibited indiscriminately the enzymatic activities of HIV‐1 RT, namely the RNA ...
Loya, Shoshana, Hizi, Amnon
openaire +2 more sources
New perspective on type 2 diabetes and obesity treatment: study and development of new natural/synthetic inhibitors of tyrosine phosphatase 1B (PTP1B). [PDF]
, 2023 Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrugs therapies to ...
Genovese, Massimo
core
Traditional and Modern Biomedical Prospecting: Part II—The Benefits
Evidence-Based Complementary and Alternative Medicine, Volume 1, Issue 2, Page 133-144, 2004., 2004 The progress in molecular and cell biology has enabled a rational exploitation of the natural resources of the secondary metabolites and biomaterials from sponges (phylum Porifera). It could be established that these natural substances are superior for biomedical application to those obtained by the traditional combinatorial chemical approach.
Werner E. G. Müller +5 more
wiley +1 more source
Chemical modification of b-lactoglobulin by quinones [PDF]
Journal of the Serbian Chemical Society, 2003 The avarone/avarol quinone/hydroquinone couple, as well as their derivatives show considerable antitumor activity. In this work, covalent modifications of b-lactoglobulin, isolated from cow milk, by avarone, its model compound 2-tert-butyl-1,4 ...
DUSAN SLADIC +5 more
doaj
Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol [PDF]
, 2015 The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio-and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3) mercaptopropionic acid (3)
De Rosa, Salvatore +4 more
core +1 more source
Protein covalent modification by biologically active quinones [PDF]
Journal of the Serbian Chemical Society, 2004 The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of b-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene-1,4,17-trione and
MIROSLAV J. GASIC +7 more
doaj
Marine invertebrate metabolites with anticancer activities: solutions to the "supply problem" [PDF]
, 2016 Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer.
Chandra, S. +4 more
core +3 more sources
Regioselektivnost konjugovane adicijena monoalkil-1,4-benzohinone [PDF]
, 2002 The regioselectivity of the reaction of conjugate addition of thiols, amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl-1,4-benzoquinone was investigated.
Božić, Tatjana T. +5 more
core +2 more sources
Bioprospecting: a CAM Frontier
, 2005 Evidence-Based Complementary and Alternative Medicine, Volume 2, Issue 1, Page 1-3, 2005.
Edwin L. Cooper
wiley +1 more source