Results 51 to 60 of about 1,115 (163)

Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2020
Background: There have been no licensed treatment options in the UK for treating thrombocytopenia in people with chronic liver disease requiring surgery.
Nigel Armstrong, Nasuh Büyükkaramikli, Hannah Penton, Rob Riemsma, Pim Wetzelaer, Vanesa Huertas Carrera, Stephanie Swift, Thea Drachen, Heike Raatz, Steve Ryder, Dhwani Shah, Titas Buksnys, Gill Worthy, Steven Duffy, Maiwenn Al, Jos Kleijnen   +15 more
doaj   +1 more source

Personalized Management of Cytopenias in Chronic Liver Disease: From Pathophysiology to Treatment Strategies. [PDF]

JGH Open
ABSTRACT Thrombocytopenia and leukopenia are among the most common hematological abnormalities in patients with chronic liver disease (CLD), particularly among those with cirrhosis. Thrombocytopenia and leukopenia are associated with increased risks of bleeding, infection, treatment delay, and poor clinical outcomes.
Wang X, Fu S, Zhu X, Zhao Y.
europepmc   +2 more sources

sj-docx-1-tag-10.1177_17562848221105976 – Supplemental material for Avatrombopag ethnic sensitivity analysis in chronic liver disease and thrombocytopenia patients: individual-level pooled analysis

, 2022
Supplemental material, sj-docx-1-tag-10.1177_17562848221105976 for Avatrombopag ethnic sensitivity analysis in chronic liver disease and thrombocytopenia patients: individual-level pooled analysis by Jun Lu, Brian D.
Brian D. Jamieson (12982869), Jun Lu (36049), Ai-Min Hui (3510203)   +2 more
core   +1 more source

Acquired Amegakaryocytic Thrombocytopenia Presenting as Pancytopenia in a Patient With Chronic Lymphocytic Leukemia: A Case Report. [PDF]

Case Rep Hematol
Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematologic disorder characterized by severe thrombocytopenia due to an isolated absence of megakaryocytes in the bone marrow, with preservation of other hematopoietic lineages. We present an 84‐year‐old man with IgHV‐mutated chronic lymphocytic leukemia (CLL), diagnosed in 1997 and managed ...
Chen CC, Shah A, Andrawis M, Benjamin J, Shah M, Fratella-Calabrese A, Chang VT.   +6 more
europepmc   +2 more sources

sj-docx-1-tah-10.1177_20406207221127532 – Supplemental material for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

, 2022
Supplemental material, sj-docx-1-tah-10.1177_20406207221127532 for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation by Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu and Yue Han in ...
Jiaqian Qi (10008962), Chengyuan Gu (441600), Depei Wu (239078), Hong Wang (13528), Yue Han (560788), Meng Zhou (105903), Ziyan Zhang (800393)   +6 more
core   +1 more source

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

American Journal of Hematology, Volume 101, Issue 10, Page 2571-2580, October 2026.
ABSTRACT Chronic liver disease (CLD)‐related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD‐related thrombocytopenia who were undergoing elective invasive ...
Yifan Han, Ning Lin, Jinghang Xu, Sikui Wang, Jinglan Jin, Jia Shang, Yongning Xin, Youwen Tan, Dazhi Zhang, Jinlin Hou, Ping An, Wen Xie, Yujuan Guan, Qingfang Xiong, Hong Wu, Huiguo Ding, Yu Chen, Rongkuan Li, Zhili Wen, Mingqin Lu, Jinhui Yang, Zhongyin Zhou, Yongjian Zhou, Zujiang Yu, Kecan Lin, Wei Wang, Yan Huang, Yuemin Nan, Xinhua Luo, Rongshu Shi, Yi Kang, Tao Han, Shiyan Chen, Kai Wang, Yunfeng Shan, Jiaping Li, Pingguo Liu, Zheng Lu, Jun Chen, Zhen Liu, Liaoyun Zhang, Li Yang, Jifang Sheng, Zhan Zeng, Yanyan Yu, Xiaoyuan Xu   +45 more
wiley   +1 more source

Long‐Term Outcomes After Elective Splenectomy for Haematological Disease: A 27‐Year Single‐Centre Study

ANZ Journal of Surgery, Volume 96, Issue 10, Page 3116-3125, October 2026.
Splenectomy is a safe and effective treatment option in selected patients with haematological disease, despite declining referrals over the last 27 years in the era of targeted therapies. Outcomes are favourable when performed laparoscopically and long‐term follow‐up demonstrates sustained haematologic benefit in surviving patients.
Salil Dutt Barrett, Anthony Downhill, Douglas Greer, William Stevenson, Ian Kerridge, Chris Ward, Matthew Greenwood, Naomi Mackinlay, Luke Coyle, Thomas J. Hugh   +9 more
wiley   +1 more source

Supplementary Material for: Efficacy and incidence of treatment related adverse events of thrombopoietin receptor agonists in adults with immune thrombocytopenia: a systematic review and network meta-analysis of randomized controlled study

, 2022
Introduction: To conduct a network meta-analysis to assess the efficacy and incidence of treatment related adverse events (TRAEs) of eltrombopag, romiplostim, avatrombopag, recombinant human thrombopoietin (rhTPO) and hetrombopag for adult immune ...
Feng C.-X. (14302397), Su J. (4665514), Geng Q.-C. (14302394), Zhang H.-X. (14302391), Lin X. (3116772), Liu Y. (597977)   +5 more
core   +1 more source

Efficacy and safety of avatrombopag in the treatment of chemotherapy-induced thrombocytopenia in children with acute lymphoblastic leukemia: a single-center retrospective study

Therapeutic Advances in Hematology
Background: Chemotherapy-induced thrombocytopenia (CIT) commonly exacerbates the difficulty of cancer treatment, increasing bleeding risks and potentially reducing chemotherapy dosage, ultimately impacting its efficacy. However, there are limited studies
Huiyan Yang, Jingyu Gao, Yongsheng Ruan, Zhaokun Chen, Ruihan Fang, Lei Zhang, Zhibiao Wang, Tiantian Yi, Qian Zhang, Yang Luo, Libai Chen, Xuedong Wu   +11 more
doaj   +1 more source

Comparative Efficacy and Safety of Thrombopoietin Receptor Agonists in Adults With Thrombocytopenia: A Systematic Review and Network Meta-analysis of Randomized Controlled Trial [PDF]

, 2021
<jats:p>Thrombopoietin receptor agonists (TPO-RAs) play a crucial role in stimulating thrombopoiesis. However, conventional meta-analyses have shown inconsistent results regarding the efficacy of thrombopoietin receptor agonists versus placebo ...
Huang, Chunlan, Wang, Long, Qin, Dalian, Hu, Haiyang, Wu, Anguo, Yang, Jing, Deng, Junzhu, Huang, Feihong, Wu, Jianming, Huang, Qianqian, Zou, Wenjun, Junzhu Deng, Jianming Wu, Long Wang, Jing Yang, Anguo Wu, Feihong Huang, Wenjun Zou, Qianqian Huang, Chunlan Huang, Haiyang Hu, Dalian Qin   +21 more
core   +1 more source