Results 71 to 80 of about 320,011 (310)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Van Der Pol-Duffing oscillator under combined harmonic and random excitations
Vietnam Journal of Mechanics, 2014 A new technique is proposed to investigate the response of Van der Pol-Duffing (V-D for short) oscillator to a combination of harmonic and random excitations in the primary resonant frequency region.
N. D. Anh, V. L. Zakovorotny, D. N. Hao
doaj +1 more source
Macroeconomic forecasting using model averaging
, 2009 PhDRecently, there has been a broadening concern on forecasting techniques that are applied on large data sets, since economists in business and management want to deal with the great magnitude of information. In this analysis, the issue of forecasting
Verra, Christina
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Upper bounds for the number of limit cycles of polynomial differential systems
Electronic Journal of Differential Equations, 2016 For $\varepsilon$ small we consider the number of limit cycles of the polynomial differential system $$ \dot{x}=y-f_1(x,y)y, \quad \dot{y}=-x-g_2(x,y)-f_2(x,y)y, $$ where $f_1(x,y)=\varepsilon f_{11}(x,y)+\varepsilon^2f_{12}(x,y)$, $g_2(x,y ...
Selma Ellaggoune, Sabrina Badi
doaj
Growth Regressions, Principal Components and Frequentist Model Averaging [PDF]
This paper offers two innovations for empirical growth research. First, the paper discusses principal components augmented regressions to take into account all available information in well-behaved regressions.
Hlouskova, Jaroslava, Wagner, Martin
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
AVERAGING IN VARIOUS COMPUTING METHODS
Information Technologies in Education, 2010 In work the role of the weighed averaging in various computing methods is shown. Communication between methods by means of the weighed averaging is shown.
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source