Results 91 to 100 of about 10,537,968 (352)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Resonances and Twist in Volume-Preserving Mappings

, 2011
The phase space of an integrable, volume-preserving map with one action and $d$ angles is foliated by a one-parameter family of $d$-dimensional invariant tori. Perturbations of such a system may lead to chaotic dynamics and transport. We show that near a
Broer H., H. R. Dullin, J. D. Meiss, Kifer Y.   +3 more
core   +1 more source

Determination of the Number of Tube Rows to Obtain Closure for Volume Averaging Theory Based Model of Fin-and-Tube Heat Exchangers

, 2011
Modelling of fin-and-tube heat exchangers based on Volume Averaging Theory (VAT) requires proper closure of the VAT based governing equations. Closure can be obtained from reasonable lower scale solutions of a CFD code, which means the tube row number ...
F. Zhou, N. Hansen, D. Geb, I. Catton
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

$S$-matrix representation of the finite temperature propagator in $\lambda\phi^4$-QFT

, 1995
The two-point Green function of the massive scalar $(3+1)$-quantum field theory with $\lambda\phi^4$ interaction at finite temperature is evaluated up to the 2nd order of perturbation theory. The averaging on the vacuum fluctuations is separated from the
Bugrij, A. I., Jenkovszky, L. L., Shadura, V. N.   +2 more
core  

Example of an inhomogeneous cosmological model in the context of backreaction

, 2016
In this article, we present an example of an inhomogeneous cosmological model, which is inspired by the linear perturbation theory. The metric of this model can be described as the Einstein-de Sitter background with a periodically distributed dust ...
Głód, Krzysztof, Sikora, Szymon
core   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

On the Periodic Orbits of Four-Particle Time-Dependent FPU Chains

Advances in Mathematical Physics, 2018
We study the existence of the periodic orbits for four-particle time-dependent FPU chains. To begin with, taking an orthogonal transformation and dropping two variables, we put the system into a lower dimensional system.
Hongwu Tang, Mingyan Xing, Qihuai Liu, Guirong Jiang   +3 more
doaj   +1 more source

A Path-integral for the Master Constraint of Loop Quantum Gravity

, 2010
In the present paper, we start from the canonical theory of loop quantum gravity and the master constraint programme. The physical inner product is expressed by using the group averaging technique for a single self-adjoint master constraint operator.
Ashtekar A, Baratin A Flori C Thiemann T, Brown L, Conway J B, Dittrich B, Dittrich B, Dittrich B, Dittrich B, Dittrich B, Engle J Han M Thiemann T, Flori C, Flori C Thiemann T, Freidel L, Giesel K, Giesel K, Giesel K, Giulini D, Giulini D, Han M, Han M Thiemann T, Han M Thiemann T, Klauder J, Muxin Han, Pietri R De, Reed M, Reisenberger M P, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T, Thiemann T   +35 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source