Results 81 to 90 of about 734,652 (287)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Quantum quenches and thermalization in SYK models
Journal of High Energy Physics, 2019 We study non-equilibrium dynamics in SYK models using quantum quench. We consider models with two, four, and higher fermion interactions (q = 2, 4, and higher) and use two different types of quench protocol, which we call step and bump quenches.
Ritabrata Bhattacharya +2 more
doaj +1 more source
Pre-Averaging Based Estimation of Quadratic Variation in the Presence of Noise and Jumps: Theory, Implementation, and Empirical Evidence [PDF]
This paper provides theory as well as empirical results for pre-averaging estimators of the daily quadratic variation of asset prices. We derive jump robust inference for pre-averaging estimators, corresponding feasible central limit theorems and an ...
Mark Podolskij, Nikolaus Hautsch
core
Extreme Value Theory for Moving Average Processes
The Annals of Probability, 1986 This is an interesting qualitative and quantitative study of extreme values of moving averages of variables with smooth tails. Let \(\{X_ t=\sum c_{\lambda -t}Z_{\lambda}\}\) be an infinite moving average process, with \(\{c_{\lambda}\}\) given constants and with the noise sequence \(\{Z_{\lambda}\}\) consisting of i.i.d. random variables.
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An asymptotic theory for model selection inference in general semiparametric problems. [PDF]
Recently, Hjort and Claeskens (2003) developed an asymptotic theory for model selection, model averaging and post-model selection/averaging inference using likelihood methods in parametric models, along with associated confidence statements.
Carroll, RJ, Claeskens, Gerda
core
Averaging operations for lattice gauge theories [PDF]
Communications in Mathematical Physics, 1985 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A Derivation of the Nonlocal Volume-Averaged Equations for Two-Phase Flow Transport
Science and Technology of Nuclear Installations, 2012 In this paper a detailed derivation of the general transport equations for two-phase systems using a method based on nonlocal volume averaging is presented.
Gilberto Espinosa-Paredes
doaj +1 more source