Results 71 to 80 of about 90,228 (264)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Limit cycles for discontinuous generalized Lienard polynomial differential equations
Electronic Journal of Differential Equations, 2013 We divide $\mathbb{R}^2$ into sectors $S_1,\dots ,S_l$, with $l>1$ even, and define a discontinuous differential system such that in each sector, we have a smooth generalized Lienard polynomial differential equation $\ddot{x}+f_i(x)\dot{x} +g_i(x)=0$,
Jaume Llibre, Ana Cristina Mereu
doaj
Periodic solutions of Lienard differential equations via averaging theory of order two
Anais da Academia Brasileira de Ciências, 2015 For ε ≠ 0sufficiently small we provide sufficient conditions for the existence of periodic solutions for the Lienard differential equations of the form x ′′ + f ( x ) x ′ + n 2 x + g ( x ) = ε 2 p 1 ( t ) + ε 3 p 2 ( t )
JAUME LLIBRE +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Limit cycles of the generalized Li'enard differential equation via averaging theory
Electronic Journal of Differential Equations, 2012 We apply the averaging theory of first and second order to a generalized Lienard differential equation. Our main result shows that for any $n,m geq 1$ there are differential equations $ddot{x}+f(x,dot{x})dot{x}+ g(x)=0$, with f and g polynomials of ...
Sabrina Badi, Amar Makhlouf
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Maximum number of limit cycles for generalized Li'enard differential equations
Electronic Journal of Differential Equations, 2013 Applying the averaging theory of first and second order to a class of generalized polynomial Lienard differential equations, we improve the known lower bounds for the maximum number of limit cycles that this class can exhibit.
Sabrina Badi, Amar Makhlouf
doaj
Nekhoroshev theory and discrete averaging
Discrete and Continuous Dynamical Systems36 ...
Gelfreich, V., Vieiro, A.
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A theory of average response to large jump perturbations [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2019 A key feature of the classical Fluctuation Dissipation theorem is its ability to approximate the average response of a dynamical system to a sufficiently small external perturbation from an appropriate time correlation function of the unperturbed dynamics of this system.
openaire +3 more sources