Results 101 to 110 of about 90,228 (264)
Kawai, Kerman, and McVoy have shown that a statistical treatment of many open channels that are coupled by direct reactions leads to modifications of the Hauser-Feshbach expression for energy-averaged cross section [Ann. of Phys. 75, 156 (1973)].
Roche K.J. +4 more
doaj +1 more source
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Periodic orbits of the spatial anisotropic Kepler problem with anisotropic perturbations
Mengyuan Li, Qihuai Liu
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Limit cycles from a cubic reversible system via the third-order averaging method
This article concerns the bifurcation of limit cycles from a cubic integrable and non-Hamiltonian system. By using the averaging theory of the first and second orders, we show that under any small cubic homogeneous perturbation, at most two limit ...
Linping Peng, Zhaosheng Feng
doaj
Periodic solutions of third order differential equations
In this paper, we study the existence of periodic solutions for the following piecewise third-order differential equation: $$ \dddot{x}+\dot{x}-\varepsilon\sum\limits_{i=1}^{2}c_i|x|^i=0, $$ with $\varepsilon$ a real parameter sufficiently small, $c_1$
Nabil Rezaiki, Amel Boulfoul
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The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Generalized Cubic Aggregation Operators with Application in Decision Making Problem
There are many aggregation operators and their applications have been developed up to date, but in this paper we introduced the idea of generalized aggregation operator.
Muhammad Shakeel +2 more
doaj

