Results 101 to 110 of about 86,720 (265)
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
This manuscript aims to find the most key steps and considerations for selecting industry 4.0 technology. For this, we evaluate the technique of circular bipolar complex fuzzy (CBCF) information.
Zeeshan Ali +4 more
doaj +1 more source
The Existence of Periodic Orbits and Invariant Tori for Some 3-Dimensional Quadratic Systems
We use the normal form theory, averaging method, and integral manifold theorem to study the existence of limit cycles in Lotka-Volterra systems and the existence of invariant tori in quadratic systems in ℝ3.
Yanan Jiang, Maoan Han, Dongmei Xiao
doaj +1 more source
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Limit cycles from a cubic reversible system via the third-order averaging method
This article concerns the bifurcation of limit cycles from a cubic integrable and non-Hamiltonian system. By using the averaging theory of the first and second orders, we show that under any small cubic homogeneous perturbation, at most two limit ...
Linping Peng, Zhaosheng Feng
doaj
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Periodic orbits of the spatial anisotropic Kepler problem with anisotropic perturbations
Mengyuan Li, Qihuai Liu
doaj
Periodic solutions of third order differential equations
In this paper, we study the existence of periodic solutions for the following piecewise third-order differential equation: $$ \dddot{x}+\dot{x}-\varepsilon\sum\limits_{i=1}^{2}c_i|x|^i=0, $$ with $\varepsilon$ a real parameter sufficiently small, $c_1$
Nabil Rezaiki, Amel Boulfoul
doaj +1 more source
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source

