Results 101 to 110 of about 86,720 (265)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

The Selection of Industry 4.0 Technologies Through Aczel-Alsina Information Based on Circular Bipolar Complex Fuzzy Uncertainty: An Operational Perspective

IEEE Access
This manuscript aims to find the most key steps and considerations for selecting industry 4.0 technology. For this, we evaluate the technique of circular bipolar complex fuzzy (CBCF) information.
Zeeshan Ali, Khumara Ashraf, Naila Siddique, Sarbast Moslem, Tapan Senapati   +4 more
doaj   +1 more source

The Existence of Periodic Orbits and Invariant Tori for Some 3-Dimensional Quadratic Systems

The Scientific World Journal, 2014
We use the normal form theory, averaging method, and integral manifold theorem to study the existence of limit cycles in Lotka-Volterra systems and the existence of invariant tori in quadratic systems in ℝ3.
Yanan Jiang, Maoan Han, Dongmei Xiao
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Limit cycles from a cubic reversible system via the third-order averaging method

Electronic Journal of Differential Equations, 2015
This article concerns the bifurcation of limit cycles from a cubic integrable and non-Hamiltonian system. By using the averaging theory of the first and second orders, we show that under any small cubic homogeneous perturbation, at most two limit ...
Linping Peng, Zhaosheng Feng
doaj  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Periodic orbits of the spatial anisotropic Kepler problem with anisotropic perturbations

Electronic Journal of Differential Equations, 2021
Mengyuan Li, Qihuai Liu
doaj  

Periodic solutions of third order differential equations

Journal of Innovative Applied Mathematics and Computational Sciences
In this paper, we study the existence of periodic solutions for the following piecewise third-order differential equation: $$ \dddot{x}+\dot{x}-\varepsilon\sum\limits_{i=1}^{2}c_i|x|^i=0, $$ with $\varepsilon$ a real parameter sufficiently small, $c_1$
Nabil Rezaiki, Amel Boulfoul
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source