Results 41 to 50 of about 734,652 (287)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Group averaging in the (p,q) oscillator representation of SL(2,R)

, 1919
We investigate refined algebraic quantisation with group averaging in a finite-dimensional constrained Hamiltonian system that provides a simplified model of general relativity.
Alberto Molgado, Azcárraga J. A., Bars I., Bars I., Bojowald M., Bojowald M., Gambini R., Giulini D., Giulini D., Giulini D., Gomberoff A., Howe R., Jorma Louko, Kastrup H. A., Landsman N. P., Landsman N. P., Louko J., Marolf D., Montesinos M., Montesinos M., Paul A., Schaller P., Shvedov O. Yu.   +22 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Periodic solutions for a class of perturbed sixth-order autonomous differential equations [PDF]

Arab Journal of Mathematical Sciences
Purpose – The objective of this work is to study the periodic solutions for a class of sixth-order autonomous ordinary differential equations x(6)+(1+p2+q2)x… .+(p2+q2+p2q2)x¨+p2q2x=εF(x,ẋ,x¨,x…,x… .,x(5)), where p and q are rational numbers different ...
Chems Eddine Berrehail, Amar Makhlouf
doaj   +1 more source

Spherically Symmetric Solutions in Macroscopic Gravity

, 2008
Schwarzschild's solution to the Einstein Field Equations was one of the first and most important solutions that lead to the understanding and important experimental tests of Einstein's theory of General Relativity.
A. Borriello, A. Krasiński, A. Paranjape, A.A. Coley, A.A. Coley, A.A. Coley, A.G. Reiss, C.M. Will, G.F.R. Ellis, J. Plebański, J.P. Boersma, J.P. Ostriker, K. Lake, L. Bergström, M. Kasai, M. Persic, M.F. Shirokov, N.V. Zotov, R. J. van den Hoogen, R.A. Isaacson, R.A. Isaacson, R.J. Hoogen van den, R.M. Zalaletdinov, R.M. Zalaletdinov, R.M. Zalaletdinov, S. Bharadwaj, S. Bildhauer, S. Perlmutter, S. Tremaine, S.W. Hawking, T. Buchert, T. Buchert, T. Futamase, T. Futamase, T.W. Noonan, T.W. Noonan, U. Nucamendi, V.C. Rubin, V.C. Rubin, V.C. Rubin, V.C. Rubin, Y. Sofue   +41 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Periodic orbits for a class of galactic potentials

, 2012
In this work, applying general results from averaging theory, we find periodic orbits for a class of Hamiltonian systems $H$ whose potential models the motion of elliptic galaxies.Comment: 8 pages, Accepted for publication in Astrophysics and Space ...
Alfaro, Felipe, Llibre, Jaume, Pérez-Chavela, Ernesto   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Limit cycles for fourth-order autonomous differential equations

Electronic Journal of Differential Equations, 2012
We provide sufficient conditions for the existence of periodic solutions of the fourth-order differential equation $$ ddddot x -(lambda+mu) dddot x +(1+lambda mu)ddot x -(lambda+mu)dot x+lambda mu x = varepsilon F(x, dot x, ddot x, dddot x ...
Jaume Llibre, Amar Makhlouf
doaj  

An approach to Atanassov's interval-valued intuitionistic fuzzy multi-attribute decision making based on prospect theory [PDF]

International Journal of Computational Intelligence Systems, 2015
Prospect theory is a very effective method to express behavioral decision making under uncertainty. This paper attempts to develop a method to multi-attribute decision making with Atanassov's interval-valued intuitionistic fuzzy information using ...
Fanyong Meng, Chunqiao Tan, Xiaohong Chen   +2 more
doaj   +1 more source