Results 71 to 80 of about 10,537,968 (352)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Group averaging in the (p,q) oscillator representation of SL(2,R)

, 1919
We investigate refined algebraic quantisation with group averaging in a finite-dimensional constrained Hamiltonian system that provides a simplified model of general relativity.
Alberto Molgado, Azcárraga J. A., Bars I., Bars I., Bojowald M., Bojowald M., Gambini R., Giulini D., Giulini D., Giulini D., Gomberoff A., Howe R., Jorma Louko, Kastrup H. A., Landsman N. P., Landsman N. P., Louko J., Marolf D., Montesinos M., Montesinos M., Paul A., Schaller P., Shvedov O. Yu.   +22 more
core   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Flexibility and analytic smoothing in averaging theory

, 2021
It has been replaced by arXiv:2209.00612, an improved, sharp version where only the steep Holder case is ...
Barbieri, Santiago, Marco, Jean-Pierre, Massetti, Jessica Elisa   +2 more
openaire   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Refined algebraic quantisation with the triangular subgroup of SL(2,R)

, 2004
We investigate refined algebraic quantisation with group averaging in a constrained Hamiltonian system whose gauge group is the connected component of the lower triangular subgroup of SL(2,R). The unreduced phase space is T^*R^{p+q} with p>0 and q>0, and
ALBERTO MOLGADO, Arfken G., Azcárraga J. A., Bargmann V., Bars I., Bojowald M., Dirac P. A. M., Erdélyi A., Gambini R., Gomberoff A., Gradshteyn I. S., Hajíček P., Henneaux M., JORMA LOUKO, Landsman N. P., Lang S., Marolf D., Marolf D., Montesinos M., Naimark M. A.   +19 more
core   +4 more sources

A theory of average response to large jump perturbations [PDF]

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2019
A key feature of the classical Fluctuation Dissipation theorem is its ability to approximate the average response of a dynamical system to a sufficiently small external perturbation from an appropriate time correlation function of the unperturbed dynamics of this system.
openaire   +4 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Periodic orbits near equilibria via averaging theory of second order

Mathematical Modelling and Analysis, 2012
Lyapunov, Weinstein and Moser obtained remarkable theorems giving sufficient conditions for the existence of periodic orbits emanating from an equilibrium point of a differential system with a first integral.
Luis Barreira, Jaume Llibre, Claudia Valls   +2 more
doaj   +1 more source

Controlled Hopwise Averaging: Bandwidth/Energy-Efficient Asynchronous Distributed Averaging for Wireless Networks [PDF]

, 2010
This paper addresses the problem of averaging numbers across a wireless network from an important, but largely neglected, viewpoint: bandwidth/energy efficiency.
Lu, Jie, Tang, Choon Yik
core