Results 71 to 80 of about 83,194 (307)

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Quantum quenches and thermalization in SYK models

open access: yesJournal of High Energy Physics, 2019
We study non-equilibrium dynamics in SYK models using quantum quench. We consider models with two, four, and higher fermion interactions (q = 2, 4, and higher) and use two different types of quench protocol, which we call step and bump quenches.
Ritabrata Bhattacharya   +2 more
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

A Derivation of the Nonlocal Volume-Averaged Equations for Two-Phase Flow Transport

open access: yesScience and Technology of Nuclear Installations, 2012
In this paper a detailed derivation of the general transport equations for two-phase systems using a method based on nonlocal volume averaging is presented.
Gilberto Espinosa-Paredes
doaj   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Limit cycles for discontinuous generalized Lienard polynomial differential equations

open access: yesElectronic Journal of Differential Equations, 2013
We divide $\mathbb{R}^2$ into sectors $S_1,\dots ,S_l$, with $l>1$ even, and define a discontinuous differential system such that in each sector, we have a smooth generalized Lienard polynomial differential equation $\ddot{x}+f_i(x)\dot{x} +g_i(x)=0$,
Jaume Llibre, Ana Cristina Mereu
doaj  

Periodic solutions of Lienard differential equations via averaging theory of order two

open access: yesAnais da Academia Brasileira de Ciências, 2015
For ε ≠ 0sufficiently small we provide sufficient conditions for the existence of periodic solutions for the Lienard differential equations of the form x ′′ + f ( x ) x ′ + n 2 x + g ( x ) = ε 2 p 1 ( t ) + ε 3 p 2 ( t )
JAUME LLIBRE   +2 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

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