Results 121 to 130 of about 202,281 (232)

Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

Nature Communications, 2015
Avian influenza viruses of the H5N1 subtype pose a serious global health threat due to the high mortality (>60%) associated with the disease caused by these viruses and the lack of protective antibodies to these viruses in the general population.
A. Taft, Makoto Ozawa, A. Fitch, Jay DePasse, P. Halfmann, Lindsay Hill-Batorski, M. Hatta, T. Friedrich, Tiago J. S. Lopes, E. Maher, E. Ghedin, C. Macken, G. Neumann, Y. Kawaoka   +13 more
semanticscholar   +1 more source

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

Dual Gene Detection of H5N1 Avian Influenza Virus Based on Dual RT-RPA

Molecules
The H5N1 avian influenza virus seriously affects the health of poultry and humans. Once infected, the mortality rate is very high. Therefore, accurate and timely detection of the H5N1 avian influenza virus is beneficial for controlling its spread.
Qian Wang, Shiwen Wu, Jiangbing Shuai, Ye Li, Xianshu Fu, Mingzhou Zhang, Xiaoping Yu, Zihong Ye, Biao Ma   +8 more
doaj   +1 more source

Genetic Characterization of Avian Influenza A(H5N6) Virus Clade 2.3.4.4, Russia, 2018

Emerging Infectious Diseases, 2019
Timely identification of pandemic influenza threats depends on monitoring for highly pathogenic avian influenza viruses. We isolated highly pathogenic avian influenza A(H5N6) virus clade 2.3.4.4, genotype G1.1, in samples from a bird in southwest Russia.
Ivan M. Susloparov, Natalia Goncharova, Natalia Kolosova, Alexey Danilenko, Vasiliy Marchenko, Galina Onkhonova, Vasiliy Evseenko, Elena Gavrilova, Rinat A. Maksutov, Alexander Ryzhikov   +9 more
doaj   +1 more source

Effectiveness of Influenza Vaccines and Duration of Protection Against Hospitalisation During the 2024/25 Season in Northern Ireland, UK

Influenza and Other Respiratory Viruses, Volume 20, Issue 8, August 2026.
ABSTRACT Background Seasonal influenza causes substantial morbidity and hospitalisation each year. We estimated influenza vaccine effectiveness (VE) against laboratory‐confirmed influenza‐associated hospitalisation among patients in Northern Ireland (NI) during the 2024/25 influenza season.
Magda Bucholc, Siobhán Murphy, Mark G. O'Doherty, Suzanne Wilton, Emma Dickson, Declan T. Bradley   +5 more
wiley   +1 more source

Phylodynamics of H5N1 avian influenza virus in Indonesia

Molecular Ecology, 2012
AbstractUnderstanding how pathogens invade and become established in novel host populations is central to the ecology and evolution of infectious disease. Influenza viruses provide unique opportunities to study these processes in nature because of their rapid evolution, extensive surveillance, large data sets and propensity to jump species boundaries ...
Leung, FCC, Holmes, EC, Lam, TTY, Hon, CC, Lemey, P, Pybus, OG, Shi, M, Li, J, Jiang, J, Tun, HM   +9 more
openaire   +5 more sources

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Determining the Environmental and Ecological Factors Associated With Poultry Farm Spillover of Highly Pathogenic Avian Influenza (H5N1) in British Columbia, Canada

Zoonoses and Public Health, Volume 73, Issue 5, Page 439-450, August 2026.
ABSTRACT Introduction Highly pathogenic avian influenza (HPAI) H5N1, clade 2.3.4.4b is a global threat causing widespread outbreaks on poultry farms and high mortality among wild bird populations in Canada. Wild aquatic birds are generally recognised as key reservoir hosts for avian influenza viruses (AIV's).
Riley Oremush, Pascale Aubry, E. Jane Parmley, Zvonimir Poljak, Amy Greer   +4 more
wiley   +1 more source

Development of a Large-Volume Concentration Method to Recover Infectious Avian Influenza Virus from the Aquatic Environment

Viruses
Since late 2021, outbreaks of highly pathogenic avian influenza virus have caused a record number of mortalities in wild birds, domestic poultry, and mammals in North America.
Laura E. Hubbard, Erin A. Stelzer, Rebecca L. Poulson, Dana W. Kolpin, Christine M. Szablewski, Carrie E. Givens   +5 more
doaj   +1 more source

Molecular Study on The Pathogenicity of Avian Influenza Virus

Indonesian Journal of Biotechnology, 2015
Highly pathogenic avian influenza virus (HPAI) differ from Low pathogenic avian influenza virus (LPAI) basedon multiple basic amino acid motif of the carboxylterminus of HA1, especially arginine and lysine.
Haryadi M. Wibowo, Heru Susetya, Tri Untari, Khrisdiana Putri, Charles Rangga Tabbu   +4 more
doaj