Results 21 to 30 of about 71,201 (184)

CRISPR/Cas9 Editing of Viral Receptors and Biotechnological Approach to Host Resistance

Proceedings, 2020
Avian sarcoma and leukosis virus (ASLV), diversified into seven phylogenetically relativesubgroups (A, B, C, D, E, J, and K), present as either exogenous or endogenous viruses in domesticchicken. [...]
Jiří Hejnar, Anna Koslová, Pavel Trefil, Jiří Plachý, Markéta Reinišová, Dana Kučerová, Jitka Mucksová, Jiří Kalina   +7 more
doaj   +1 more source

Plaque assay of avian sarcoma viruses using casein [PDF]

Journal of Virology, 1975
The caseinolytic activity of several strains of Rous sarcoma virus (RSV), conditional and nonconditional mutants of RSV, and nontransforming avian leukosis viruses was investigated. Only those viruses capable of transforming chick fibroblasts in vitro induced lysis of casein incorporated into an agar overlay.
P C, Balduzzi, H, Murphy
openaire   +2 more sources

Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion. [PDF]

PLoS Pathogens, 2011
A large group of viruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral nucleocapsid.
Naveen K Jha, Olga Latinovic, Erik Martin, Gennadiy Novitskiy, Mariana Marin, Kosuke Miyauchi, John Naughton, John A T Young, Gregory B Melikyan   +8 more
doaj   +1 more source

The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda

Viruses, 2019
Jan Svoboda triggered investigations on non-defective avian sarcoma viruses. These viruses were a critical factor in the genetic understanding of retroviruses.
Peter K. Vogt
doaj   +1 more source

Cell Transformation by RNA Viruses: An Overview

Viruses, 2011
Studies of oncogenic viruses have made seminal contributions to the molecular biology of cancer. Key discoveries include the identification of viral oncogenes and cellular proto-oncogenes, elucidation of signal transduction pathways, and identification ...
Hung Fan
doaj   +1 more source

Multifunctional miR-155 Pathway in Avian Oncogenic Virus-Induced Neoplastic Diseases

Non-Coding RNA, 2019
MicroRNAs (miRNAs) are small noncoding RNAs that fine-tune the responses of the cell by modulating the cell transcriptome and gene expression. MicroRNA 155 (miR-155) is a conserved multifunctional miRNA involved in multiple roles including the modulation
Megha Sravani Bondada, Yongxiu Yao, Venugopal Nair   +2 more
doaj   +1 more source

Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses

Frontiers in Immunology, 2018
Innate antiviral immunity establishes first line of defense against invading pathogens through sensing their molecular structures such as viral RNA. This antiviral potential of innate immunity is mainly attributed to a myriad of IFN-stimulated genes ...
Mohammed A. Rohaim, Mohammed A. Rohaim, Mohammed A. Rohaim, Diwakar Santhakumar, Rania F. El Naggar, Munir Iqbal, Hussein A. Hussein, Muhammad Munir   +7 more
doaj   +1 more source

Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses

Retrovirology, 2005
Background Retrovirus infection depends on binding of the retroviral envelope (Env) protein to specific cell-surface protein receptors. Interference, or superinfection resistance, is a frequent consequence of retroviral infection, and occurs when newly ...
Van Hoeven Neal S, Miller A
doaj   +1 more source

Reverse Engineering Provides Insights on the Evolution of Subgroups A to E Avian Sarcoma and Leukosis Virus Receptor Specificity

Viruses, 2019
The initial step of retrovirus entry—the interaction between the virus envelope glycoprotein trimer and a cellular receptor—is complex, involving multiple, noncontiguous determinants in both proteins that specify receptor choice, binding ...
Mark J. Federspiel
doaj   +1 more source

Mutations in Both the Surface and Transmembrane Envelope Glycoproteins of the RAV-2 Subgroup B Avian Sarcoma and Leukosis Virus Are Required to Escape the Antiviral Effect of a Secreted Form of the Tvb^S3 Receptor †

Viruses, 2019
The subgroup A through E avian sarcoma and leukosis viruses ASLV(A) through ASLV(E) are a group of highly related alpharetroviruses that have evolved to use very different host protein families as receptors. We have exploited genetic selection strategies
Xueqian Yin, Deborah C. Melder, William S. Payne, Jerry B. Dodgson, Mark J. Federspiel   +4 more
doaj   +1 more source