Results 61 to 70 of about 84,978 (308)

Underlying cause of infant mortality in Distrito Federal, Brazil : 1990 to 2000 [PDF]

open access: yes, 2004
OBJETIVOS: caracterizar a tendência da mortalidade infantil no Distrito Federal por causa básica de morte e segundo causas evitáveis entre 1990 e 2000. MÉTODOS: estudo ecológico a partir do total de óbitos infantis e nascimentos ocorridos, utilizando-se ...
Monteiro, Renata Alves   +1 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Diferenciais entre homens e mulheres na mortalidade evitável no Brasil (1983-2005) Gender differences in avoidable mortality in Brazil (1983-2005)

open access: yesCadernos de Saúde Pública, 2009
O objetivo do estudo foi analisar a mortalidade de homens e mulheres em municípios brasileiros entre 1983 e 2005, segundo três grupamentos de causas de morte evitáveis: evitáveis por diagnóstico e tratamento precoce, evitáveis por melhoria no tratamento ...
Daisy Maria Xavier de Abreu   +2 more
doaj   +1 more source

Aiming Higher: Results From a State Scorecard on Health System Performance [PDF]

open access: yes, 2007
Assesses state variation across key dimensions of health system performance -- access, quality, avoidable hospital use and costs, equity, and healthy lives -- and assigns overall state rankings as well as ranks on each ...
Cathy Schoen   +4 more
core  

Avoiding Death by Vacuum

open access: yesJournal of Physics: Conference Series, 2013
The two-Higgs doublet model (2HDM) can have two electroweak breaking, CP-conserving, minima. The possibility arises that the minimum which corresponds to the known elementary particle spectrum is metastable, a possibility we call the "panic vacuum".
A Barroso   +4 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Time trends in avoidable cancer mortality in Lithuania 1992–2008

open access: yesActa Medica Lituanica, 2011
Background. This study was aimed to evaluate achievements of medical health care services in Lithuania by analysing time trends in avoidable cancer mortality of the whole Lithuanian population from 1992 through 2008. Materials and methods.
Giedre SMAILYTE, Laurynas PAREIGIS
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A Price Worth Paying: The Case for Controlling Marine Emissions in the Pearl River Delta [PDF]

open access: yes, 2012
The Pearl River Delta (PRD) is a region with a single airshed, but different administrative and legal practices for controlling air quality. Under the Regional Cooperation Plan on Building a Quality Living Area (QLA Plan) released in June 2012 the ...
Agnes Yip   +14 more
core  

Association between reduced stillbirth rates in England and regional uptake of accreditation training in customised fetal growth assessment [PDF]

open access: yes, 2013
Objective: To assess the effect that accreditation training in fetal growth surveillance and evidence-based protocols had on stillbirth rates in England and Wales. Design: Analysis of mortality data from Office of National Statistics.
Clifford, Sally   +4 more
core   +1 more source

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