Results 51 to 60 of about 187,393 (352)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Study on Creep Compression Characteristics of Pressure-Bearing Graded Crushed Rock
BuildingsTo study the creep compression characteristics and evolution mechanism of pressure-bearing graded crushed rock under constant load. Creep compression tests of crushed rock were conducted using the self-developed confined compression test system under ...
Yu Tian +4 more
doaj +1 more source
Advances in Civil Engineering, 2021 The body of the new-type dry gas holder is a large stiffened cylindrical shell. Limited by the test site and economic conditions, the buckling characteristics of such holders are generally studied through scale model experiments.
Jiawei Ding +3 more
doaj +1 more source
In Vitro Studies for Investigating Creep of Intervertebral Discs under Axial Compression: A Review of Testing Environment and Results [PDF]
, 2022 Mengying Yang +3 more
openalex +1 more source
The Effects of Air and Underwater Blast on Composite Sandwich Panels and Tubular Laminate Structures
, 2012 The resistance of glass-fibre reinforced polymer (GFRP) sandwich panels and laminate tubes to blast in air and underwater environments has been studied.
A Neuberger +13 more
core +1 more source
New tension-compression damage model for complex analysis of concrete structures [PDF]
, 2016 A new damage model, based on continuum damage mechanics and simulating the opening, closing, and reopening of cracks in concrete using only one surface of discontinuity, is proposed in this article.
Barbat Barbat, Horia Alejandro +2 more
core +2 more sources
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Vertical facing panel-joint gap analysis for steel-seinforced soil walls [PDF]
, 2016 This paper reports the results of a numerical parametric study focused on the prediction of vertical load distribution and vertical gap compression between precast concrete facing panel units in steel-reinforced soil walls ranging in height from 6 to 24 ...
Bathurst, Richard +3 more
core +2 more sources
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source