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The imaging crisis in axial spondyloarthritis.
The Lancet RheumatologyImaging holds a pivotal yet contentious role in the early diagnosis of axial spondyloarthritis. Although MRI has enhanced our ability to detect early inflammatory changes, particularly bone marrow oedema in the sacroiliac joints, the poor specificity of ...
Torsten Diekhoff, Denis Poddubnyy
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HLA-B27, axial spondyloarthritis and survival
Annals of the Rheumatic Diseases, 2023Introduction Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy individuals, are reportedly associated with increased mortality.
Zhixiu Li +8 more
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News in the treatment of axial spondyloarthritis
Vnitřní lékařství, 2022Axial spondyloarthritis is a rheumatic disease characterized by inflammation and bone formation causing impaired function of the spine and affected joints. Basic research has highlighted the key role of dysregulation of tumor necrosis factor α, interleukin- 23 and interleukin-17 cytokine production in the etiology of axial spondyloarthritis. Tumor
Martin, Žurek, Pavel, Horák
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Axial Imaging in Spondyloarthritis
Rheumatic Disease Clinics of North AmericaImaging plays a crucial role in diagnosing and forecasting treatment outcomes in axial spondyloarthritis. Conventional radiography may overlook patients in the initial stages of the disease, while MRI is sensitive in identifying inflammation early on. Computed tomography reliably detects structural abnormalities. Practicing rheumatologists must possess
Vishnu, Mohan, Mark C, Hwang
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Treatment overview of axial spondyloarthritis in 2023.
Baillière's Best Practice & Research : Clinical Rheumatology, 2023The treatment of patients with axial spondyloarthritis (axSpA) is characterized by non-pharmacological and pharmacological treatment options. It may depend on the type and extent of musculoskeletal and extramusculoskeletal manifestations.
X. Baraliakos +3 more
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Biomarkers in axial spondyloarthritis
Current Opinion in Rheumatology, 2015To assess the literature for biomarker validation studies that address key unmet needs related to the evaluation and management of patients with axial spondyloarthritis (SpA). This review focused on biomarkers facilitating early diagnosis and reflecting disease activity, structural damage on radiography, and clinical response to major therapies.Early ...
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Navigating the complexity of pain in psoriatic arthritis and axial spondyloarthritis
Current Opinion in RheumatologyPurpose of review Pain is the most common and often most troublesome feature of chronic autoimmune diseases such as psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA).
P. Mease
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Golimumab for the treatment of axial spondyloarthritis
Expert Review of Clinical Immunology, 2015Axial spondyloarthritis (axSpA) is a chronic, immune-mediated inflammatory disease of the axial skeleton that includes ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients with AS experience chronic pain due to sacroiliac joint and spinal inflammation, and may develop spinal ankylosing with syndesmophyte ...
Gita, Gelfer, Lisa, Perry, Atul, Deodhar
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Golimumab for the treatment of axial spondyloarthritis
Expert Opinion on Biological Therapy, 2016Anti-TNF drugs have represented an epochal revolution in the treatment of rheumatoid arthritis and spondyloarthritis. In the field of axial spondyloarthritis, golimumab, a fully human monoclonal anti-TNFα administered subcutaneously every 4 weeks, has shown significant efficacy and good safety in patients with ankylosing spondylitis.
Carlo, Palazzi +5 more
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The Future of Imaging in Axial Spondyloarthritis
Rheumatic Disease Clinics of North America, 2020This article discusses the current position of conventional radiography and MRI, the techniques recommended by the European League Against Rheumatism for use in imaging in axial spondyloarthritis (axSpA). Several challenges and areas of development regarding radiography and MRI in axSpA are considered.
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