Results 101 to 110 of about 2,423,960 (318)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Does the Beighton Score Correlate With Specific Measures of Shoulder Joint Laxity?

Orthopaedic Journal of Sports Medicine, 2018
Background: Evaluation of shoulder joint laxity is an important component of the shoulder examination, especially in the setting of shoulder instability.
Noah A. Whitehead MBChB, Khalid D. Mohammed MBChB, FRACS, Mark L. Fulcher MBChB, MMedSci, FACSEP   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Correlation between machining direction, cutter geometry and step-over distance in 3-axis milling: Application to milling by zones. [PDF]

, 2012
Computer-Aided Manufacturing (CAM) occupies an increasingly important role in engineering with all it has to offer in terms of new possibilities and improving designer/manufacturer productivity. The present study addresses machining of free-form surfaces
Senatore, Johanna, Rubio, Walter, Segonds, Stéphane, Dessein, Gilles   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Biodynamics of the seated human body with dual-axis excitation: nonlinearity and cross-axis coupling

, 2012
The apparent mass of the seated human body and the transmissibility to the upper-body (i.e., the spine and the pelvis) during vertical vibration excitation have been reported to have resonance frequencies around 5 Hz.
Zheng, Guangtai
core  

Élesztőgyártól a levéltárig — A Schneider-palota története

Axis
Az Eötvös utca 7. szám alatti Schneider-palota jelenleg az Állambiztonsági Szolgálatok Történeti Levéltárának ad otthont, amelynek fő feladata az 1945 és 1990 között működő politikai rendőrség különböző szervei által keletkeztetett iratanyagok őrzése és
Nóra Szekér
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Performance evaluation of three cross flow vertical axis wind turbine configurations.

, 2009
The performance output of three Vertical Axis Wind Turbine (VAWT) configurations has been evaluated using a two-dimensional Computational Fluid Dynamic (CFD) model. Data has been obtained using a quasi-steady Multi Reference Frame (MRF) approach in which
Rao, H.V., Colley, Gareth, Mishra, Rakesh, Woolhead, R.   +3 more
core  

Női rabbik a zsidóságban

Axis, 2013
A zsidóságban a Jeruzsálemi Templom és a Második Szentély Kr. e. 70-ben történt lerombolása óta nincsenek papok. A rabbi vallási tanító, a zsidó vallási tanok ismerője, nem a vallás papja. Szellemi vezető, és e tekintetben vallási vezető.
Antónia Szász
doaj