Results 91 to 100 of about 2,423,960 (318)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The influence of Blade Chord on the Aerodynamics and Performance of Vertical Axis Wind Turbines [PDF]

open access: yes, 2013
The climate change due to emissions from the combustion of fossil fuel to meet the ever increasing energy demands of the growing world population has roused the attention of governments and individuals to protect the environment.
Eboibi, Okeoghene
core  

Five-Axis Machine Tool Condition Monitoring Using dSPACE Real-Time System

open access: yes, 2012
This paper presents the design, development and SIMULINK implementation of the lumped parameter model of C-axis drive from GEISS five-axis CNC machine tool.
Longstaff, Andrew P.   +7 more
core   +1 more source

Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients [PDF]

open access: yes, 2008
Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals.
Bondy, Brigitta   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

A sailwing vertical axis wind turbine for small scale applications [PDF]

open access: yes
The use of sailwing aerofoils in vertical axis wind turbines has been investigated. It was anticipated that this could make vertical axis turbines more suitable for water pumping and that this might help to meet the need for a cheap pump for ...
Revell, Philip Scott
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Measurement of large on-axis and off-axis mirrors using software configurable optical test system

open access: yes, 2018
One of the major challenges of optical fabrication is measurement of the surface when first polished out, before its figure is within the capture range of interferometry.
Oh, Chang Jin   +4 more
core   +1 more source

Measurement of neutrino oscillation parameters from muon neutrino disappearance with an off-axis beam [PDF]

open access: yes, 2013
The T2K Collaboration reports a precision measurement of muon neutrino disappearance with an off-axis neutrino beam with a peak energy of 0.6 GeV. Near detector measurements are used to constrain the neutrino flux and cross section parameters.
A. Ereditato   +999 more
core   +1 more source

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