Results 141 to 150 of about 304,829 (369)

Tensed axons are on fire

Proceedings of the National Academy of Sciences
Already in the late 19th / early 20th century, neuroscientists such as Wilhelm His, Ross Granville Harrison, and Paul Weiss, discussed the role of mechanical signals in neuronal development (1-4). A few decades later, in two seminal papers, Dennis Bray showed that extending neuronal processes (‘neurites’) are under tension, and that the external ...
openaire   +3 more sources

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

Nature, 2011
A formidable challenge in neural repair in the adult central nervous system (CNS) is the long distances that regenerating axons often need to travel in order to reconnect with their targets.
Fang Sun, Kevin K. Park, Stéphane Belin, Dongqing Wang, Tao Lu, Gang Chen, Kang Zhang, C. Yeung, G. Feng, B. Yankner, Zhigang He   +10 more
semanticscholar   +1 more source

Strategies to avoid a missed diagnosis of co-occurring concussion in post-acute patients having a spinal cord injury

Neural Regeneration Research, 2015
Research scientists and clinicians should be aware that missed diagnoses of mild-moderate traumatic brain injuries in post-acute patients having spinal cord injuries may approach 60-74% with certain risk factors, potentially causing clinical consequences
David S Kushner
doaj   +1 more source

Imine Crosslinked, Injectable, and Self‐Healing Fucoidan Hydrogel with Immunomodulatory Properties

Advanced Healthcare Materials, EarlyView.
This study develops an injectable fucoidan‐based hydrogel with tunable properties for tissue engineering. By oxidizing fucoidan (OFu) to introduce aldehydes, imine crosslinks are formed with amine‐containing polymers, enabling self‐healing, injectability, and long‐term stability (≥28 days). The OFu‐gelatin hydrogel demonstrated biocompatibility, immune‐
Asma Talib Qureshi, Shajia Afrin, Saad Asim, Muhammad Rizwan   +3 more
wiley   +1 more source

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

Journal of Neuroscience, 2013
Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a wide range of neurological disorders.
Josiah Gerdts, Daniel W. Summers, Y. Sasaki, A. Diantonio, J. Milbrandt   +4 more
semanticscholar   +1 more source

New Aspects of the Pathogenesis of Canine Distemper Leukoencephalitis

Viruses, 2014
Canine distemper virus (CDV) is a member of the genus morbillivirus, which is known to cause a variety of disorders in dogs including demyelinating leukoencephalitis (CDV-DL).
Charlotte Lempp, Ingo Spitzbarth, Christina Puff, Armend Cana, Kristel Kegler, Somporn Techangamsuwan, Wolfgang Baumgärtner, Frauke Seehusen   +7 more
doaj   +1 more source

Degenerations of the Dog Retina : VII. Central Non-Progressive Degeneration due to an Anomaly of the Ganglion Cells and their Axons [PDF]

, 1955
H. B. Parry
openalex   +1 more source

One‐Shot Remote Integration of Macromolecular Synaptic Elements on a Chip for Ultrathin Flexible Neural Network System

Advanced Materials, EarlyView.
A novel one‐shot integration electropolymerization (OSIEP) method is developed as a breakthrough on the intricate photolithographic steps, enabling to compress all processes from synthesis to channel integration in one‐shot manufacturing. The specially designed dual bipolar electrodes provide the targeted depositions of poly(3,4‐ethylenedioxythiophene)
Jiyun Lee, Jaehoon Lee, Hyeonsu Bang, Tae Woong Yoon, Jong Hwan Ko, Guobing Zhang, Ji‐Sang Park, Il Jeon, Sungjoo Lee, Boseok Kang   +9 more
wiley   +1 more source

Efficacy assessment of an active tau immunotherapy in Alzheimer’s disease patients with amyloid and tau pathology: a post hoc analysis of the “ADAMANT” randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trialResearch in context

EBioMedicine
Summary: Background: Tau pathology correlates with and predicts clinical decline in Alzheimer’s disease. Approved tau-targeted therapies are not available.
Nicholas C. Cullen, Petr Novak, Duygu Tosun, Branislav Kovacech, Jozef Hanes, Eva Kontsekova, Michal Fresser, Stefan Ropele, Howard H. Feldman, Reinhold Schmidt, Bengt Winblad, Norbert Zilka   +11 more
doaj